https://scholars.lib.ntu.edu.tw/handle/123456789/553341
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | CHIA-TUNG SHUN | en_US |
dc.contributor.author | MING-SHIANG WU | en_US |
dc.contributor.author | Lin J.-T. | en_US |
dc.contributor.author | HSIU-PO WANG | en_US |
dc.contributor.author | Houng R.-L. | en_US |
dc.contributor.author | Lee W.-J. | en_US |
dc.contributor.author | Wang T.-H. | en_US |
dc.contributor.author | Chuang S.-M. | en_US |
dc.date.accessioned | 2021-03-18T02:03:40Z | - |
dc.date.available | 2021-03-18T02:03:40Z | - |
dc.date.issued | 1998 | - |
dc.identifier.issn | 0172-6390 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/553341 | - |
dc.description.abstract | BACKGROUND/AIMS: Reduced expression of E-cadherin leading to loss of cellular adhesion is crucial for cancer invasion and metastasis. The aim of this study is to investigate the role of E-cadherin in gastric tumorigenesis. METHODOLOGY: Immunohistochemical expression of E-cadherin was analyzed and correlated with clinicopathological characteristics of 122 patients with gastric cancer. RESULTS: Reduced E-cadherin expression was noted in 71 tumors (58.2%), while all normal epithelium showed a normal expression. Correlation of E-cadherin status to histological subtypes and growth patterns revealed a significantly higher frequency of reduced expression in diffuse type (46/60, 76.7%), advanced tumors (48/68, 70.6%) and stage III/IV (39/53, 73.6%) than that in intestinal type (25/62, 40.3%, p < 0.0001), early tumors (23/54, 42.6%, p < 0.005) and stage I/II (32/69, 46.4%, p < 0.005) respectively. Moreover, abnormal expression was more frequent in tumors with positive lymph node metastasis (45/62, 72.6%), peritoneum seeding (10/11, 90.9%) and venous permeation (27/37, 73%) than that in tumors without lymph node metastasis (26/60, 43.3%, p < 0.005), peritoneum seeding (61/111, 55.0%, p < 0.05) and venous permeation (44/85, 51.8%, p < 0.05). There is no statistical difference between E-cadherin expression and the status of perineural invasion or H. pylori infection. Analysis of survival for patients demonstrated that reduced E-cadherin expression was correlated with poor prognosis. CONCLUSIONS: These data indicate that impaired expression of E-cadherin is an important characteristic of gastric cancer and contributes to histogenesis, tumor growth, metastasis and poor survival. | en_US |
dc.relation.ispartof | Hepato-Gastroenterology | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | uvomorulin; article; cancer growth; cancer staging; cancer survival; clinical feature; controlled study; helicobacter pylori; human; human tissue; immunohistochemistry; lymph node metastasis; major clinical study; peritoneum metastasis; priority journal; prognosis; protein expression; stomach cancer; stomach epithelium; Cadherins; Humans; Immunoenzyme Techniques; Lymphatic Metastasis; Neoplasm Metastasis; Stomach Neoplasms; Survival Rate | - |
dc.title | An immunohistochemical study of E-cadherin expression with correlations to clinicopathologioal features in gastric cancer | en_US |
dc.type | journal article | en |
dc.identifier.pmid | 9755986 | - |
dc.identifier.scopus | 2-s2.0-0031692570 | - |
dc.relation.pages | 944-949 | en_US |
dc.relation.journalvolume | 45 | en_US |
dc.relation.journalissue | 22 | en_US |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Forensic Medicine | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0002-0468-4468 | - |
crisitem.author.orcid | 0000-0002-1940-6428 | - |
crisitem.author.orcid | 0000-0002-7741-9315 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 法醫學科所 |
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