https://scholars.lib.ntu.edu.tw/handle/123456789/558325
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | SHYANG-RONG SHIH | en_US |
dc.contributor.author | SHU-LANG LIAO | en_US |
dc.contributor.author | Shih, Chih-Wei | en_US |
dc.contributor.author | YI-HSUAN WEI | en_US |
dc.contributor.author | Lu, Ting-Xuan | en_US |
dc.contributor.author | Chou, Chien-Hsiang | en_US |
dc.contributor.author | Yen, Er-Yen | en_US |
dc.contributor.author | YI-CHENG CHANG | en_US |
dc.contributor.author | CHIA-CHI LIN | en_US |
dc.contributor.author | Chi, Yu-Chiao | en_US |
dc.contributor.author | WEI-SHIUNG YANG | en_US |
dc.contributor.author | FENG-CHIAO TSAI | en_US |
dc.date.accessioned | 2021-04-29T06:22:30Z | - |
dc.date.available | 2021-04-29T06:22:30Z | - |
dc.date.issued | 2021-01-02 | - |
dc.identifier.issn | 09273948 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/558325 | - |
dc.description.abstract | Purpose: Orbital fibroblasts are involved in pathogenesis of Graves' orbitopathy (GO). Fibroblast growth factor (FGF) affects fibroblasts of GO. This study aims to investigate the roles of FGF and FGF receptor (FGFR) in GO.Methods: Serum FGF proteins and orbital fibroblast FGFR proteins and mRNAs were measured in GO patients and controls. Orbital fibroblasts of GO were cultured and accessed for changes in proliferation (by nuclei number and MTT), myofibroblastic differentiation (by α-SMA), and adipogenesis (by oil droplets using Oil Red O stain) under FGF1 with or without FGFR inhibitors (FGFRi).Results: Serum FGF1 and FGF2 were increased in GO patients. FGFR1 was the most abundantly expressed FGFR in GO orbital fibroblasts. FGF1 increased GO fibroblast proliferation/adipogenesis and suppressed myofibroblastic differentiation, while FGFRi reversed these effects.Conclusion: FGF signaling may be involved in GO pathogenesis. Manipulation of FGF-FGFR pathway for GO treatment is worthy of further investigation.Registration number on Clinicaltrials.gov: NCT03324022. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Ocular immunology and inflammation | en_US |
dc.subject | Adipogenesis; Graves’ orbitopathy; fibroblast growth factor receptors; fibroblast growth factors; myofibroblast | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | cyclosporine; fibroblast growth factor 1; fibroblast growth factor 2; fibroblast growth factor receptor 1; fibroblast growth factor receptor 2; fibroblast growth factor receptor 3; fibroblast growth factor receptor 4; immunoglobulin; messenger RNA; methyl | - |
dc.title | Fibroblast Growth Factor Receptor Inhibitors Reduce Adipogenesis of Orbital Fibroblasts and Enhance Myofibroblastic Differentiation in Graves' Orbitopathy | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1080/09273948.2019.1672196 | - |
dc.identifier.pmid | 31657648 | - |
dc.identifier.scopus | 2-s2.0-85074612968 | - |
dc.identifier.url | https://scholars.lib.ntu.edu.tw/handle/123456789/494701 | - |
dc.relation.journalvolume | 29 | en_US |
dc.relation.journalissue | 1 | en_US |
dc.relation.pageend | 202 | en_US |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Medicine-NTUCC | - |
crisitem.author.dept | Ophthalmology | - |
crisitem.author.dept | Ophthalmology-NTUH | - |
crisitem.author.dept | Division of Oculoplasty and Neuro-Ophthalmology | - |
crisitem.author.dept | Ophthalmology | - |
crisitem.author.dept | Ophthalmology-NTUH | - |
crisitem.author.dept | Division of Oculoplasty and Neuro-Ophthalmology | - |
crisitem.author.dept | Medical Genomics and Proteomics | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Oncology-NTUH | - |
crisitem.author.dept | Clinical Medicine | - |
crisitem.author.dept | Pharmacology | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.orcid | 0000-0001-7424-1358 | - |
crisitem.author.orcid | 0000-0002-4312-5351 | - |
crisitem.author.orcid | 0000-0002-2087-9855 | - |
crisitem.author.orcid | 0000-0002-8077-5011 | - |
crisitem.author.orcid | 0000-0001-5087-373X | - |
crisitem.author.orcid | 0000-0001-9615-6023 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Cancer Center (NTUCC) | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | Ophthalmology-NTUH | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | Ophthalmology-NTUH | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。