https://scholars.lib.ntu.edu.tw/handle/123456789/558476
標題: | Relationship between periodontal disease and mortality in patients treated with maintenance hemodialysis | 作者: | Chen L.-P. CHIH-KANG CHIANG Peng Y.-S. Hsu S.-P. Lin C.-Y. CHUN-FU LAI KUAN-YU HUNG |
公開日期: | 2011 | 卷: | 57 | 期: | 2 | 起(迄)頁: | 276-282 | 來源出版物: | American Journal of Kidney Diseases | 摘要: | Background The relationship between periodontitis and outcomes in patients treated with long-term hemodialysis is controversial. Our previous work suggests that periodontitis is associated with malnutrition and inflammation. Here, we hypothesize that periodontitis is associated with mortality in hemodialysis patients. Study Design Prospective observational study. Setting & Participants 253 patients undergoing hemodialysis at a single hospital-based dialysis facility. Predictor Severity of periodontal disease (mild, moderate, or severe based on oral examination of 6 teeth). Outcomes & Measurements All-cause and cardiovascular mortality during a 6-year follow-up after an oral health examination of index teeth. Results During the 6-year follow-up, 102 patients died. Death occurred in 70.6%, 41.8%, and 24.0% of patients with severe, moderate, and mild/no periodontitis, respectively. Using mild/no periodontitis as the reference group and adjustment for demographic characteristics, comorbid conditions, and selected laboratory values, HRs for all-cause mortality were 1.39 (95% CI, 0.83-2.34) and 1.83 (95% CI, 1.04-3.24) for moderate and severe periodontitis, respectively. HRs for cardiovascular mortality were not statistically significant. Limitations Single assessment of periodontal disease severity. Conclusions For patients undergoing long-term hemodialysis, periodontitis is associated with increased risk of death. Clinical trials are required to determine whether treatment of periodontitis decreases mortality. ? 2011 National Kidney Foundation, Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-78751618594&doi=10.1053%2fj.ajkd.2010.09.016&partnerID=40&md5=387c90f6be6e0ac879abaf8768f0d7cb https://scholars.lib.ntu.edu.tw/handle/123456789/558476 |
ISSN: | 0272-6386 | DOI: | 10.1053/j.ajkd.2010.09.016 | SDG/關鍵字: | adult; article; clinical trial; disease severity; female; hemodialysis; human; kidney failure; long term care; male; mortality; mouth examination; observational study; periodontitis; Aged; Chronic Disease; Comorbidity; Female; Follow-Up Studies; Humans; Inflammation; Kaplan-Meier Estimate; Kidney Diseases; Male; Malnutrition; Middle Aged; Periodontal Diseases; Prevalence; Prospective Studies; Renal Dialysis; Severity of Illness Index; Treatment Outcome |
顯示於: | 醫學系 |
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