https://scholars.lib.ntu.edu.tw/handle/123456789/558553
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Wang P.-H. | en_US |
dc.contributor.author | SHU-YUNG LIN | en_US |
dc.contributor.author | Lee S.S.-J. | en_US |
dc.contributor.author | SHU-WEN LIN | en_US |
dc.contributor.author | CHIH-YUAN LEE | en_US |
dc.contributor.author | Wei Y.-F. | en_US |
dc.contributor.author | CHIN-CHUNG SHU | en_US |
dc.contributor.author | JANN-YUAN WANG | en_US |
dc.contributor.author | CHONG-JEN YU | en_US |
dc.creator | Wang P.-H.;Lin S.-Y.;Lee S.S.-J.;Lin S.-W.;Lee C.-Y.;Wei Y.-F.;Shu C.-C.;Jann-Yuan Wang;Yu C.-J. | - |
dc.date.accessioned | 2021-05-02T04:37:07Z | - |
dc.date.available | 2021-05-02T04:37:07Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85097284223&doi=10.1038%2fs41598-020-78374-3&partnerID=40&md5=c04b2b1305ef9f0563c2d2edbf9941b1 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/558553 | - |
dc.description.abstract | A significantly negative reversion in the QuantiFERON-TB Gold In-tube (QFT-GIT) test is reported in patients on dialysis, which makes the results unreliable. The CD4 and CD8 responses of the QFT-Gold plus (QFT-Plus) may have better positive consistency, but this needs to be investigated. We enrolled dialysis patients with baseline positive QFT-GIT0 results and conducted two rounds of follow-up paired QFT-GIT1&2 and QFT-Plus1&2 tests at an interval of 6?months. The positive consistency, concordance, and discordance of the QFT results were analyzed. A total of 236 patients on dialysis were screened, and 73 participants with positive QFT-GIT0 results were enrolled. The baseline QFT-GIT0 response was higher in the 1st QFT-Plus1(+) group than in the QFT-Plus1(?) group, but insignificantly different between the 1st QFT-GIT1(+) and QFT-GIT1(?) groups. The two assays had good correlation when concurrently tested. Fifty-three subjects completed a second round of the QFT-GIT2 and QFT-Plus2. Persistent positivity was higher with the QFT-Plus2 (81.8%) than with the QFT-GIT2 (58.8%, p = 0.040). The QFT-GIT1 and QFT-Plus1 CD4 responses were higher in patients with persistent positivity than in those with negative reversion, whereas the difference of the QFT-Plus TB1 and TB2 data, representative of the CD8 response, were similar between positive persistence and negative reversion. In conclusion, the QFT-Plus provides more reliable positive consistency than does the QFT-GIT. The CD4 interferon-γ response might play a role in maintaining positivity of LTBI. ? 2020, The Author(s). | en_US |
dc.publisher | Nature Research | en_US |
dc.relation.ispartof | Scientific Reports | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | biological marker; adult; aged; blood; CD8+ T lymphocyte; female; health care delivery; hemodialysis; human; immunology; interferon gamma release assay; latent tuberculosis; male; metabolism; middle aged; risk factor; Adult; Aged; Biomarkers; CD8-Positive T-Lymphocytes; Delivery of Health Care; Female; Humans; Interferon-gamma Release Tests; Latent Tuberculosis; Male; Middle Aged; Renal Dialysis; Risk Factors | - |
dc.title | CD4 response of QuantiFERON-TB Gold Plus for positive consistency of latent tuberculosis infection in patients on dialysis | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1038/s41598-020-78374-3 | - |
dc.identifier.pmid | 33288814 | - |
dc.identifier.scopus | 2-s2.0-85097284223 | - |
dc.relation.pages | 21367 | en_US |
dc.relation.journalvolume | 10 | en_US |
dc.relation.journalissue | 1 | en_US |
item.fulltext | no fulltext | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Clinical Pharmacy | - |
crisitem.author.dept | Pharmacy | - |
crisitem.author.dept | School of Pharmacy | - |
crisitem.author.dept | Pharmacy-NTUCC | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUHHC | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | National Taiwan University Hospital Hsin-Chu Branch | - |
crisitem.author.dept | NTU BioMedical Park Hospital | - |
crisitem.author.orcid | 0000-0001-6826-3403 | - |
crisitem.author.orcid | 0000-0002-9940-0850 | - |
crisitem.author.orcid | 0000-0001-5034-3544 | - |
crisitem.author.orcid | 0000-0003-0311-5148 | - |
crisitem.author.orcid | 0000-0003-3406-366X | - |
crisitem.author.orcid | 0000-0001-5664-9392 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Cancer Center (NTUCC) | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | NTU Hsin-Chu Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital Hsin-Chu Branch | - |
顯示於: | 醫學系 |
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