https://scholars.lib.ntu.edu.tw/handle/123456789/560571
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | KAI-CHIEN YANG | en_US |
dc.contributor.author | Nerbonne J.M. | en_US |
dc.date.accessioned | 2021-05-07T06:48:00Z | - |
dc.date.available | 2021-05-07T06:48:00Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 10501738 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/560571 | - |
dc.description.abstract | In the mammalian heart, multiple types of K+ channels contribute to the control of cardiac electrical and mechanical functioning through the regulation of resting membrane potentials, action potential waveforms and refractoriness. There are similarly vast arrays of K+ channel pore-forming and accessory subunits that contribute to the generation of functional myocardial K+ channel diversity. Maladaptive remodeling of K+ channels associated with cardiac and systemic diseases results in impaired repolarization and increased propensity for arrhythmias. Here, we review the diverse transcriptional, post-transcriptional, post-translational, and epigenetic mechanisms contributing to regulating the expression, distribution, and remodeling of cardiac K+ channels under physiological and pathological conditions. ? 2016 Elsevier Inc. | - |
dc.relation.ispartof | Trends in Cardiovascular Medicine | - |
dc.subject | Arrhythmias; Cardiac hypertrophy; Diabetes; Heart failure; Long non-coding RNAs; MicroRNAs; Myocardial excitability; Transcription factors | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | lipid; long untranslated RNA; potassium channel; long untranslated RNA; potassium; potassium channel; atrial fibrillation; diabetes mellitus; epigenetics; gene expression; genetic transcription; heart disease; heart failure; heart infarction; heart muscle ischemia; heart ventricle hypertrophy; human; molecular mechanics; pathogenesis; physiological process; posttranscriptional gene silencing; priority journal; protein processing; regulatory mechanism; Review; action potential; cardiac muscle; gene expression regulation; genetics; heart atrium remodeling; heart disease; heart rate; heart ventricle remodeling; male; metabolism; pathology; pathophysiology; RNA processing; signal transduction; Action Potentials; Atrial Remodeling; Gene Expression Regulation; Heart Diseases; Heart Rate; Humans; Male; Myocardium; Potassium; Potassium Channels; RNA Processing, Post-Transcriptional; RNA, Long Noncoding; Signal Transduction; Transcription, Genetic; Ventricular Remodeling | - |
dc.title | Mechanisms contributing to myocardial potassium channel diversity, regulation and remodeling | en_US |
dc.type | review | en |
dc.identifier.doi | 10.1016/j.tcm.2015.07.002 | - |
dc.identifier.pmid | 26391345 | - |
dc.relation.pages | 209-218 | - |
dc.relation.journalvolume | 26 | - |
dc.relation.journalissue | 3 | - |
item.fulltext | no fulltext | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
item.openairetype | review | - |
crisitem.author.dept | Pharmacology | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Center for Frontier Medicine | - |
crisitem.author.orcid | 0000-0002-9128-9166 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 藥理學科所 |
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