https://scholars.lib.ntu.edu.tw/handle/123456789/561048
標題: | Antimicrobial susceptibilities and molecular typing of neisseria gonorrhoeae isolates at a medical centre in Taiwan, 2001–2013 with an emphasis on high rate of azithromycin resistance among the isolates | 作者: | Liu Y.-H. YU-TSUNG HUANG Liao C.-H. PO-REN HSUEH |
公開日期: | 2018 | 卷: | 51 | 期: | 5 | 起(迄)頁: | 768-774 | 來源出版物: | International Journal of Antimicrobial Agents | 摘要: | A high prevalence of gonococcal resistance to various antimicrobials and Neisseria gonorrhoeae isolates exhibiting resistance to extended-spectrum cephalosporins have been reported in the past few decades. A total of 226 N. gonorrhoeae isolates obtained from the National Taiwan University Hospital from 2001 to 2013 were evaluated. The minimum inhibitory concentrations (MICs) of the isolates to antimicrobials were determined by the agar dilution method and interpreted using the 2017 clinical breakpoints or epidemiological cut-off values recommended by the Clinical and Laboratory Standards Institute (CLSI) and European Committee on Antimicrobial Susceptibility Testing (EUCAST). The genetic relatedness of these isolates was determined by multilocus sequence typing. None of the isolates was resistant to ceftriaxone and cefotaxime, and the resistance rates to cefixime, spectinomycin, cefpodoxime, ciprofloxacin, and penicillin were 0.4%, 0.4%, 13.3%, 91.6%, and 87.6%, respectively. The rate of isolates resistant to azithromycin was 14.6% (EUCAST criteria), which is higher than in previous surveillance studies. A total of 57 sequence types (ST) were identified, and ST1901, ST7365, and ST1927 prevailed. Isolates of ST8143 emerged after 2011. ST1901 isolates had relatively higher MIC values for ceftriaxone and azithromycin than those of the other STs. In conclusion, ceftriaxone remains an effective drug of choice for gonorrhoeal management in Taiwan. High rates of azithromycin resistance among N. gonorrhoeae isolates were found. The circulating ST1901 strains with high MIC values for ceftriaxone and azithromycin and the emerging ST8143 strains were alarming. ? 2018 Elsevier B.V. and International Society of Chemotherapy |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/561048 | ISSN: | 0924-8579 | DOI: | 10.1016/j.ijantimicag.2018.01.024 | SDG/關鍵字: | ABC transporter; adenylate kinase; azithromycin; cefixime; cefotaxime; cefpodoxime; ceftriaxone; ciprofloxacin; fumarate hydratase; glucose 6 phosphate dehydrogenase; penicillin derivative; phosphoglucomutase; spectinomycin; antiinfective agent; azithromycin; cephalosporin derivative; abcZ gene; adk gene; adult; agar dilution; antibiotic resistance; antibiotic sensitivity; aroE gene; Article; bacterial gene; bacterial strain; bacterium isolate; controlled study; female; fumC gene; gdh gene; human; major clinical study; male; minimum inhibitory concentration; molecular typing; multilocus sequence typing; Neisseria gonorrhoeae; nonhuman; pdhC gene; pgm gene; priority journal; retrospective study; Taiwan; antibiotic resistance; drug effect; genetics; gonorrhea; Human immunodeficiency virus infection; isolation and purification; microbial sensitivity test; microbiology; Neisseria gonorrhoeae; vagina; Adult; Anti-Bacterial Agents; Azithromycin; Cephalosporins; Drug Resistance, Bacterial; Female; Gonorrhea; HIV Infections; Humans; Male; Microbial Sensitivity Tests; Multilocus Sequence Typing; Neisseria gonorrhoeae; Taiwan; Vagina |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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