https://scholars.lib.ntu.edu.tw/handle/123456789/561151
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Lin S.-H. | en_US |
dc.contributor.author | Liao W.-H. | en_US |
dc.contributor.author | Lai C.-C. | en_US |
dc.contributor.author | Tan C.-K. | en_US |
dc.contributor.author | Liao C.-H. | en_US |
dc.contributor.author | YU-TSUNG HUANG | en_US |
dc.contributor.author | Wang C.-Y. | en_US |
dc.contributor.author | PO-REN HSUEH | en_US |
dc.date.accessioned | 2021-05-18T05:57:04Z | - |
dc.date.available | 2021-05-18T05:57:04Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0924-8579 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/561151 | - |
dc.description.abstract | Hospital-associated invasive pneumococcal disease (HA-IPD) is infrequently reported. A retrospective surveillance of IPD in a medical centre in Taiwan was conducted from 2000 to 2008 to compare the clinical and microbiological characteristics of HA-IPD and community-associated IPD (CA-IPD). HA-IPD was identified in 37 patients, comprising 12.3% of the 302 hospitalised patients with IPD. Patients with HA-IPD were more likely to have solid-organ cancer (40.5% vs. 16.6%; P=0.001) or to have received immunosuppressive therapy (56.8% vs. 26.8%; P<0.001). The 30-day mortality rate of HA-IPD was significantly higher than that of CA-IPD (40.5% vs. 16.2%; P=0.001). Age ?65 years [odds ratio (OR). =2.10; P=0.033], HA-IPD (OR. =2.90; P=0.009) and liver cirrhosis (OR. =3.19; P=0.009) were independent predictors of 30-day mortality. No significant differences in serotype distribution or in susceptible rates to penicillin (18.2% vs. 32.6%; P=0.14) and cefotaxime (60.6% vs. 67.8%; P=0.53) were found between HA-IPD and CA-IPD isolates. Similar prevalences of the serotypes included in the pneumococcal vaccines were found in isolates from patients with HA-IPD and CA-IPD. Among patients with HA-IPD and CA-IPD, 26 (78.8%) and 172 (73.2%) (P=0.45) had isolates of serotypes included in the 7-valent pneumococcal conjugate vaccine, and 30 (90.9%) and 224 (95.3%) (P=0.96) had isolates of serotypes included in the 23-valent pneumococcal polysaccharide vaccine, respectively. In summary, this study found that HA-IPD and CA-IPD were not significantly different with regard to serotype distribution and antimicrobial susceptibility in Taiwan. Patients with HA-IPD have a higher mortality rate, and pneumococcal vaccination for patients at increased risk for HA-IPD should be encouraged. ? 2010 Elsevier B.V. and the International Society of Chemotherapy. | - |
dc.relation.ispartof | International Journal of Antimicrobial Agents | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | cefotaxime; penicillin G; Pneumococcus vaccine; adolescent; adult; aged; antibiotic sensitivity; article; bacterium isolate; child; clinical article; clinical feature; controlled study; disease association; female; hospital infection; human; immunosuppressive treatment; liver cirrhosis; male; mortality; neoplasm; outcome assessment; pneumococcal infection; preschool child; priority journal; school child; serotype; Taiwan; Adult; Age Factors; Aged; Anti-Bacterial Agents; Cefotaxime; Community-Acquired Infections; Cross Infection; Female; Humans; Immunosuppressive Agents; Liver Cirrhosis; Male; Neoplasms; Penicillins; Pneumococcal Infections; Pneumococcal Vaccines; Retrospective Studies; Risk Factors; Serotyping; Streptococcus pneumoniae; Taiwan; Treatment Outcome; Vaccines, Conjugate | - |
dc.title | Comparison of clinical features, antimicrobial susceptibility, serotype distribution and outcomes of patients with hospital- and community-associated invasive pneumococcal disease | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.ijantimicag.2010.04.001 | - |
dc.identifier.pmid | 20472403 | - |
dc.identifier.scopus | 2-s2.0-77953808229 | - |
dc.relation.pages | 119-123 | - |
dc.relation.journalvolume | 36 | - |
dc.relation.journalissue | 2 | - |
item.fulltext | no fulltext | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Laboratory Medicine-NTUH | - |
crisitem.author.dept | Laboratory Medicine | - |
crisitem.author.dept | Laboratory Medicine | - |
crisitem.author.dept | Laboratory Medicine-NTUH | - |
crisitem.author.orcid | 0000-0002-7805-4178 | - |
crisitem.author.orcid | 0000-0002-7502-9225 | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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