https://scholars.lib.ntu.edu.tw/handle/123456789/561161
標題: | Impact of pneumococcal vaccines on invasive pneumococcal disease in Taiwan | 作者: | Liao W.-H. Lin S.-H. Lai C.-C. Tan C.-K. Liao C.-H. YU-TSUNG HUANG Wang C.-Y. PO-REN HSUEH |
公開日期: | 2010 | 卷: | 29 | 期: | 4 | 起(迄)頁: | 489-492 | 來源出版物: | European Journal of Clinical Microbiology and Infectious Diseases | 摘要: | In Taiwan, the 23-valent pneumococcal polysaccharide vaccine (PPV23) and the 7-valent pneumococcal conjugate vaccine (PCV7) have been available since January 2001 and October 2005, respectively. A hospital-based surveillance of invasive pneumococcal disease (IPD) in a medical center was conducted from 2000 to 2008 to evaluate the epidemiologic changes after pneumococcal vaccination. A total of 337 episodes in 328 patients were identified. The cumulative coverage rate of PPV23 among persons of age ?75 years increased from 12% in 2007 to 41% in 2008, and that of PCV7 among children aged <5 years was 0.7% in 2005 and 25.2% in 2008. The annual incidence of IPD decreased from 6.2 cases per 10,000 hospitalizations in 2000-2005 to 3.8 cases in 2006-2008 (38.5% reduction, P < 0.001), but the fatality rate did not change significantly (24.4% and 21.8%, P = 0.74). The serotype coverage rates of PPV23 and PCV7 were not significantly different between 2000-2005 and 2006-2008 (both P > 0.05). A marked increase of serotype 19A from 2000-2005 (0.5%) to 2006-2008 (11.5%) was found (P < 0.001). In summary, a decline in IPD incidence but not in fatality rate occurred after the availability of PCV7 and the increased usage of PPV23. The rapid emergence of serotype 19A during this period is alarming. ? 2010 Springer-Verlag. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/561161 | ISSN: | 0934-9723 | DOI: | 10.1007/s10096-010-0873-7 | SDG/關鍵字: | Pneumococcus vaccine; adult; aged; article; bacterium culture; bacterium isolate; child; controlled study; disease association; disease classification; disease surveillance; female; hospital based case control study; hospitalization; human; major clinical study; male; mortality; patient identification; pneumococcal infection; preschool child; priority journal; serotyping; Streptococcus pneumoniae; Taiwan; vaccination; Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Female; Hospitals; Humans; Incidence; Infant; Infant, Newborn; Male; Middle Aged; Pneumococcal Infections; Pneumococcal Vaccines; Serotyping; Streptococcus pneumoniae; Taiwan; Young Adult |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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