https://scholars.lib.ntu.edu.tw/handle/123456789/561167
Title: | Strain relatedness of meticillin-resistant Staphylococcus aureus isolates recovered from patients with repeated bacteraemia | Authors: | Liao C.-H. Lai C.-C. SHEY-YING CHEN YU-TSUNG HUANG PO-REN HSUEH |
Issue Date: | 2010 | Journal Volume: | 16 | Journal Issue: | 5 | Start page/Pages: | 463-469 | Source: | Clinical Microbiology and Infection | Abstract: | Information on the relatedness of isolates causing repeated meticillin-resistant Staphylococcus aureus (MRSA) bacteraemia is limited. An observational study of 177 patients with MRSA bacteraemia, admitted to the emergency department of National Taiwan University Hospital, was conducted from January 2001 to June 2006. Among these patients, 28 had a previous episode of MRSA bacteraemia and 59 died during the index episode of bacteraemia. Until December 2007, among the 118 patients who survived the index episode (101 without previous bacteraemia and 17 with previous bacteraemia), 24 (20.3%) had repeated MRSA bacteraemia. The duration from discontinuation of antimicrobial therapy to repeat episodes was in the range 35-854 days (median 86 days). Eight patients (33.3%) died as a result of the second bacteraemic episode. Clinical characteristics associated with repeated bacteraemia included the diagnosis of infective endocarditis and active malignancy. Pulsed-field gel electrophoresis and multilocus sequence typing analysis were performed for 32 pairs of available isolates recovered from patients with repeated bacteraemia and revealed that 29 of them (90.6%) were genetically closely-related strains. The majority of patients with repeated MRSA bacteraemia had recurrent infections and a high mortality rate. ? 2009 The Authors. Journal Compilation ? 2009 European Society of Clinical Microbiology and Infectious Diseases. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/561167 | ISSN: | 1198-743X | DOI: | 10.1111/j.1469-0691.2009.02885.x | SDG/Keyword: | antiinfective agent; adolescent; adult; aged; antimicrobial therapy; article; bacterial endocarditis; bacterial strain; bacterium isolate; controlled study; disease association; disease duration; female; human; major clinical study; male; methicillin resistant Staphylococcus aureus; methicillin resistant Staphylococcus aureus infection; mitotic recombination; mortality; multilocus sequence typing; nonhuman; priority journal; pulsed field gel electrophoresis; recurrent infection; survival rate; methicillin resistant Staphylococcus aureus; Staphylococcus aureus |
Appears in Collections: | 醫學院附設醫院 (臺大醫院) |
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