https://scholars.lib.ntu.edu.tw/handle/123456789/561236
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | WEI-LIANG SHIH | en_US |
dc.contributor.author | MING-WHEI YU | en_US |
dc.contributor.author | PEI-JER CHEN | en_US |
dc.contributor.author | Wu T.-W. | en_US |
dc.contributor.author | Lin C.-L. | en_US |
dc.contributor.author | CHUN-JEN LIU | en_US |
dc.contributor.author | Lin S.-M. | en_US |
dc.contributor.author | Tai D.-I. | en_US |
dc.contributor.author | Lee S.-D. | en_US |
dc.contributor.author | Liaw Y.-F. | en_US |
dc.date.accessioned | 2021-05-18T07:11:43Z | - |
dc.date.available | 2021-05-18T07:11:43Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 1018-4813 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/561236 | - |
dc.description.abstract | A region on chromosome 4q25 has recently been highlighted as linked to hepatocellular carcinoma (HCC). In this study, we performed a family-based association analysis with 67 single-nucleotide polymorphisms (SNPs) to map this linkage region in 240 families with HCC, 212 (88.3%) of which were ascertained through hepatitis B virus surface antigen (HBsAg)-positive index cases. Individual SNP analysis with correction for multiple testing identified 10 SNPs in two correlated haplotype blocks, located in or around the 3′-phosphoadenosine 5′-phosphosulfate synthetase-1 (PAPSS1) gene (all P-values: <0.0075). Our linkage data and GIST (Genotype identity-by-descent sharing test) indicate that 6 of these 10 SNPs contributed to the linkage signal. The haplotype block of the strongest association with HCC extended from the intron 5 to the 3′-flanking region of PAPSS1; multiple consecutive three-SNP haplotypes in this region were significant. The most significant haplotype showed odd ratios of 3.41 (95% confidence interval (CI)=1.36-8.53) for homozygous individuals in a case-unaffected sibling analysis. This haplotype also revealed an association with elevated serum α-fetoprotein and with poor survival in familial cases and an independent series of HBsAg-positive cases with small tumor present at the time of hospital admission. These results implicate PAPSS1 as a candidate HCC-susceptibility gene in hepatitis B carriers. | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.ispartof | European Journal of Human Genetics | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | adenosine 3' phosphate 5' phosphosulfate; adenosine 3' phosphate 5' phosphosulfate 1; alpha fetoprotein; hepatitis B surface antigen; unclassified drug; adult; aged; article; cancer survival; chromosome 4q; controlled study; DNA flanking region; gene locus; gene mapping; genetic association; genetic linkage; haplotype; homozygosity; human; intron; liver cell carcinoma; major clinical study; priority journal; protein blood level; single nucleotide polymorphism; Hepatitis B virus | - |
dc.title | Evidence for association with hepatocellular carcinoma at the PAPSS1 locus on chromosome 4q25 in a family-based study | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1038/ejhg.2009.48 | - |
dc.identifier.pmid | 19337310 | - |
dc.identifier.scopus | 2-s2.0-84984578402 | - |
dc.relation.pages | 1250-1259 | - |
dc.relation.journalvolume | 17 | - |
dc.relation.journalissue | 10 | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Epidemiology and Preventive Medicine | - |
crisitem.author.dept | Epidemiology and Preventive Medicine | - |
crisitem.author.dept | Public Health | - |
crisitem.author.dept | Clinical Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0002-4160-7541 | - |
crisitem.author.orcid | 0000-0002-8371-6236 | - |
crisitem.author.orcid | 0000-0001-8316-3785 | - |
crisitem.author.orcid | 0000-0002-6202-0993 | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 流行病學與預防醫學研究所 |
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