Skip navigation
  • 中文
  • English

DSpace CRIS

  • DSpace logo
  • Home
  • Organizations
  • Researchers
  • Research Outputs
  • Explore by
    • Organizations
    • Researchers
    • Research Outputs
  • Academic & Publications
  • Sign in
  • 中文
  • English
  1. NTU Scholars
  2. 醫學院
  3. 醫學系
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/561929
DC FieldValueLanguage
dc.contributor.authorJANG-MING LEEen_US
dc.contributor.authorWu M.-T.en_US
dc.contributor.authorLee Y.-C.en_US
dc.contributor.authorYang S.-Y.en_US
dc.contributor.authorJIN-SHING CHENen_US
dc.contributor.authorHSAO-HSUN HSUen_US
dc.contributor.authorPEI-MING HUANGen_US
dc.contributor.authorSHUENN-WEN KUOen_US
dc.contributor.authorLee C.-J.en_US
dc.contributor.authorChen C.-J.en_US
dc.date.accessioned2021-05-24T03:42:07Z-
dc.date.available2021-05-24T03:42:07Z-
dc.date.issued2005-
dc.identifier.issn1078-0432-
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-27644551365&doi=10.1158%2f1078-0432.CCR-04-2333&partnerID=40&md5=23a6ebda585b3210a1c7c91a7767d9b8-
dc.identifier.urihttps://scholars.lib.ntu.edu.tw/handle/123456789/561929-
dc.description.abstractPurpose: Activity of glutathione S-transferase (GST) is associated with detoxification of xenobiotics and the maintenance of cell viability. Genetically variant GSTs produce different enzymatic activities. The clinical significance of this variation is still puzzling. We investigated whether genetic polymorphisms of GST including GSTP1, GSTM1, and GSTT1 affect survival among esophageal cancer patients. Experimental Design: From 1996 to 2002,233 patients with pathologically proven esophageal cancer were recruited from the Department of Surgery, National Taiwan University Hospital. GST genotypes, including GSTT1, GSTM1, and GSTP1, were determined by PCR or PCR-RFLP. The influence of the genetic polymorphisms on patient survival was estimated using the method of Kaplan-Meier survival function and Cox proportional hazards models. Results: The mean survival times (months) of the GSTP1 Ile/Ile, Ile/Val, and Val/Val were 11,10, and 7, respectively (P < 0.05), The more the patients carried GSTP1 variant Val alleles, the poorer the survival rate (adjusted hazard ratio, 1.36; 95% confidence interval, 1.01-1.84; Ptrend=0.045). In contrast, no association of GSTT1 or GSTM1 genotypes with survival rate was noted. Conclusion: The presence of the GSTP1 variant allele (Val) is associated with a poorer prognosis of esophageal cancer. ? 2005 American Association for Cancer Research.-
dc.relation.ispartofClinical Cancer Research-
dc.subject.otherantineoplastic agent; cisplatin; fluorouracil; glutathione transferase; glutathione transferase M1; glutathione transferase P1; glutathione transferase T1; isoleucine; paclitaxel; unclassified drug; valine; adult; aged; article; cancer adjuvant therapy; cancer radiotherapy; cancer surgery; cancer survival; cell viability; enzyme activity; esophagus cancer; female; gene; genetic polymorphism; genetic variability; genotype; GSTP1 gene; human; human tissue; Kaplan Meier method; major clinical study; male; nonbiological model; pathology; polymerase chain reaction; priority journal; prognosis; restriction fragment length polymorphism; survival time; xenobiotic metabolism; Adult; Aged; Aged, 80 and over; Alleles; Esophageal Neoplasms; Female; Gene Frequency; Genotype; Humans; Male; Middle Aged; Neoplasm Staging; Polymorphism, Genetic; Survival Analysis-
dc.subject.other[SDGs]SDG3-
dc.titleAssociation of GSTP1 polymorphism and survival for esophageal canceren_US
dc.typejournal article-
dc.identifier.doi10.1158/1078-0432.CCR-04-2333-
dc.identifier.pmid16000570-
dc.identifier.scopus2-s2.0-27644551365-
dc.relation.pages4749-4753-
dc.relation.journalvolume11-
dc.relation.journalissue13-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_6501-
item.openairetypejournal article-
item.fulltextno fulltext-
item.cerifentitytypePublications-
crisitem.author.deptSurgery-NTUH-
crisitem.author.deptSurgery-
crisitem.author.deptSurgery-NTUH-
crisitem.author.deptSurgery-
crisitem.author.deptSurgery-NTUH-
crisitem.author.deptSurgery-
crisitem.author.deptSurgery-NTUH-
crisitem.author.deptSurgery-
crisitem.author.deptSurgery-NTUH-
crisitem.author.deptSurgery-
crisitem.author.orcid0000-0001-9727-227X-
crisitem.author.orcid0000-0001-5077-4483-
crisitem.author.orcid0000-0002-0376-1206-
crisitem.author.orcid0000-0001-5493-7673-
crisitem.author.orcid0000-0001-5026-5582-
crisitem.author.parentorgNational Taiwan University Hospital-
crisitem.author.parentorgCollege of Medicine-
crisitem.author.parentorgNational Taiwan University Hospital-
crisitem.author.parentorgCollege of Medicine-
crisitem.author.parentorgNational Taiwan University Hospital-
crisitem.author.parentorgCollege of Medicine-
crisitem.author.parentorgNational Taiwan University Hospital-
crisitem.author.parentorgCollege of Medicine-
crisitem.author.parentorgNational Taiwan University Hospital-
crisitem.author.parentorgCollege of Medicine-
Appears in Collections:醫學系
Show simple item record

SCOPUSTM   
Citations

48
checked on Mar 6, 2023

WEB OF SCIENCETM
Citations

44
checked on Mar 19, 2023

Page view(s)

31
checked on Mar 27, 2023

Google ScholarTM

Check

Altmetric

Altmetric

Related Items in TAIR


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

總館學科館員 (Main Library)
醫學圖書館學科館員 (Medical Library)
社會科學院辜振甫紀念圖書館學科館員 (Social Sciences Library)

開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

  • 請確認所上傳的全文是原創的內容,若該文件包含部分內容的版權非匯入者所有,或由第三方贊助與合作完成,請確認該版權所有者及第三方同意提供此授權。
    Please represent that the submission is your original work, and that you have the right to grant the rights to upload.
  • 若欲上傳已出版的全文電子檔,可使用Sherpa Romeo網站查詢,以確認出版單位之版權政策。
    Please use Sherpa Romeo to find a summary of permissions that are normally given as part of each publisher's copyright transfer agreement.
  • 網站簡介 (Quickstart Guide)
  • 使用手冊 (Instruction Manual)
  • 線上預約服務 (Booking Service)
  • 方案一:臺灣大學計算機中心帳號登入
    (With C&INC Email Account)
  • 方案二:ORCID帳號登入 (With ORCID)
  • 方案一:定期更新ORCID者,以ID匯入 (Search for identifier (ORCID))
  • 方案二:自行建檔 (Default mode Submission)
  • 方案三:學科館員協助匯入 (Email worklist to subject librarians)
Build with DSpace-CRIS - Extension maintained and optimized by Logo 4SCIENCE Feedback