https://scholars.lib.ntu.edu.tw/handle/123456789/562533
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Liaw Y.-S. | en_US |
dc.contributor.author | Tsai-Wu J.-J. | en_US |
dc.contributor.author | Wu C.-H. | en_US |
dc.contributor.author | CHIEN-CHING HUNG | en_US |
dc.contributor.author | Lee C.-N. | en_US |
dc.contributor.author | PAN-CHYR YANG | en_US |
dc.contributor.author | KWEN-TAY LUH | en_US |
dc.contributor.author | Kuo S.-H. | en_US |
dc.date.accessioned | 2021-05-26T03:35:08Z | - |
dc.date.available | 2021-05-26T03:35:08Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 1027-3719 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/562533 | - |
dc.description.abstract | SETTING: National Taiwan University Hospital, Taipei, Taiwan. OBJECTIVE: To study the variations in the NRAMP1 gene using five genotypes (274C/T, 577-18G/A, A318V, D543N and 3′ untranslated region [UTR]), and the susceptibility of tuberculosis and HIV infection in Taiwanese. DESIGN: The study sample included 49 patients with tuberculosis, 48 healthy control subjects and 60 HIV-infected patients. The polymerase chain reaction (PCR) products amplified from their genomic DNA were subjected to restriction enzyme digestion and were analysed using agarose gel electrophoresis. RESULTS: A318V was not polymorphic in the studied population. Only D543N and 3′UTR were more heterozygous. In 274 C/T and 577-18G/A, the allele frequencies showed the predominant type to be the homozygous patterns C/C (94%) and G/G (94%), respectively. There were no statistically significant differences between the tuberculosis patients and the healthy control subjects. Despite the high susceptibility to Mycobacterium tuberculosis in HIV-infected patients, genotypic frequencies in the HIV-positive patients were not significantly different between tuberculous (n = 29) and nontuberculous patients (n = 31). In comparison with previous studies, there were significant differences between different ethnic groups in allele frequencies for 274C/T, D543N and 3′UTR. CONCLUSION: The allele and genotype of NRAMP1 polymorphism among Taiwanese differed from those of Caucasians, Africans and Hispanics. No allelic associations were identified between the NRAMP1 alleles and tuberculosis susceptibility. | en_US |
dc.relation.ispartof | International Journal of Tuberculosis and Lung Disease | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | genomic DNA; natural resistance associated macrophage protein 1; 3' untranslated region; adolescent; adult; agar gel electrophoresis; aged; article; child; controlled study; DNA polymorphism; female; gene frequency; genetic resistance; genetic susceptibility; genotype; heterozygosity; homozygosity; human; Human immunodeficiency virus infection; major clinical study; male; Mycobacterium tuberculosis; polymerase chain reaction; priority journal; Taiwan; tuberculosis; Adult; Aged; Cation Transport Proteins; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Male; Middle Aged; Polymerase Chain Reaction; Polymorphism, Genetic; Taiwan; Tuberculosis | - |
dc.title | Variations in the NRAMP1 gene and susceptibility of tuberculosis in Taiwanese | en_US |
dc.type | journal article | en |
dc.identifier.pmid | 12019922 | - |
dc.identifier.scopus | 2-s2.0-0036248837 | - |
dc.relation.pages | 454-460 | en_US |
dc.relation.journalvolume | 6 | en_US |
dc.relation.journalissue | 5 | en_US |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Tropical Medicine and Parasitology | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Clinical Medicine | - |
crisitem.author.dept | Clinical Pharmacy | - |
crisitem.author.dept | Oncology | - |
crisitem.author.dept | Biomedical Electronics and Bioinformatics | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Laboratory Medicine | - |
crisitem.author.orcid | 0000-0001-7345-0836 | - |
crisitem.author.orcid | 0000-0001-6330-6048 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Electrical Engineering and Computer Science | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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