https://scholars.lib.ntu.edu.tw/handle/123456789/563983
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | WEN-PIN CHEN | en_US |
dc.contributor.author | Chi T.-C. | en_US |
dc.contributor.author | LEE-MING CHUANG | en_US |
dc.contributor.author | MING-JAI SU | en_US |
dc.date.accessioned | 2021-05-31T06:18:08Z | - |
dc.date.available | 2021-05-31T06:18:08Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 142999 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/563983 | - |
dc.description.abstract | The present study investigated the effect of resveratrol on the electrophysiology and insulin secretion of pancreatic beta cells, and examined resveratrol-induced alterations in insulin levels and plasma glucose of normal and streptozotocin-induced diabetic rats. Whole-cell voltage clamp study in the MIN6 cell, a mouse β cell line, revealed that resveratrol significantly inhibited ATP-sensitive K+ current at 3?μmol/l, and voltage-gated K+ currents at 30?μmol/l. Ca2+-activated K+ current was activated by resveratrol at 100?μmol/l. In MIN6 cells stained with membrane potential dye DiBAC4(5), resveratrol markedly depolarized membrane potential at the concentrations of 3-100?μmol/l. Insulin secretion was increased in the presence of resveratrol in MIN6, Hit-T15, and RIN-m5F cells. Resveratrol (3?mg/kg, i.p.) increased insulin secretion associated with a lowering in plasma glucose in normal rats, but not in streptozotocin-diabetic rats within the initial 60?min. In conclusion, resveratrol can act as an insulin-secretagogue through IKATP and IKV inhibition which can contribute to plasma glucose lowering effect in normal rats. ? 2007 Elsevier B.V. All rights reserved. | en_US |
dc.relation.ispartof | European Journal of Pharmacology | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | adenosine triphosphate; adenosine triphosphate sensitive potassium channel; bis(1,3 dibutylbarbituric acid)pentamethine oxonol; calcium activated potassium channel; dye; glucose; insulin; potassium channel; resveratrol; streptozocin; unclassified drug; animal cell; animal experiment; animal model; article; concentration response; controlled study; drug mechanism; electrophysiology; glucose blood level; insulin blood level; insulin release; male; membrane depolarization; membrane potential; mouse; nonhuman; pancreas islet beta cell; potassium current; priority journal; rat; streptozocin diabetes; voltage clamp; Animals; Blood Glucose; Cell Line, Tumor; Cricetinae; Diabetes Mellitus, Experimental; Insulin; Insulin-Secreting Cells; Male; Membrane Potentials; Mice; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Wistar; Stilbenes | - |
dc.title | Resveratrol enhances insulin secretion by blocking KATP and KV channels of beta cells | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.ejphar.2007.04.062 | - |
dc.identifier.pmid | 17573071 | - |
dc.identifier.scopus | 2-s2.0-34250854589 | - |
dc.relation.pages | 269-277 | en_US |
dc.relation.journalvolume | 568 | en_US |
dc.relation.journalissue | 1月3日 | en_US |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Pharmacology | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Pharmacology | - |
crisitem.author.orcid | 0000-0002-0143-5642 | - |
crisitem.author.orcid | 0000-0003-0978-2662 | - |
crisitem.author.orcid | 0000-0001-8887-6899 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 藥理學科所 |
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