https://scholars.lib.ntu.edu.tw/handle/123456789/564794| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Lee C.-C. | en_US |
| dc.contributor.author | Chang D.-M. | en_US |
| dc.contributor.author | Huang K.-F. | en_US |
| dc.contributor.author | Chen C.-L. | en_US |
| dc.contributor.author | Chen T.-C. | en_US |
| dc.contributor.author | Lo Y. | en_US |
| dc.contributor.author | JIH-HWA GUH | en_US |
| dc.contributor.author | Huang H.-S. | en_US |
| dc.date.accessioned | 2021-06-02T05:43:42Z | - |
| dc.date.available | 2021-06-02T05:43:42Z | - |
| dc.date.issued | 2013 | - |
| dc.identifier.issn | 9680896 | - |
| dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84885858566&doi=10.1016%2fj.bmc.2013.09.006&partnerID=40&md5=1bc02fdffcfd30e64375a25b6303f72d | - |
| dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/564794 | - |
| dc.description.abstract | A series of 2,7-diamidofluorenones were designed, synthesized, and screened by SRB assay. Some synthesized compounds exhibited antitumor activities in submicromolar range. Ten compounds (3a, 3b, 3c, 3g, 3j, 3l, 4a, 4h, 4i, and 4j) were also selected by NCI screening system and 3c (GI50 = 1.66 μM) appeared to be the most active agent of this series. Furthermore, 3c attenuated topoisomerase I-mediated DNA relaxation at low micromolar concentrations. These results indicated that fluorenones have potential to be further developed into anticancer drugs. ? 2013 Elsevier Ltd. All rights reserved. | - |
| dc.relation.ispartof | Bioorganic and Medicinal Chemistry | - |
| dc.subject | Fluorenones; NCI 60-cell panel assay; Tilorone; Topoisomerase I | - |
| dc.subject.other | 2,7 bis(3 chloropropionamido) 9 fluorenone; 2,7 bis(chloroacetamido) 9 fluorenone; 2,7 bis[2 (butylamino)acetamido] 9 fluorenone; 2,7 bis[2 (ethylthio)acetamido] 9 fluorenone; 2,7 bis[2 (isobutylamino)acetamido] 9 fluorenone; 2,7 bis[2 (isopropylamino)acetamido] 9 fluorenone; 2,7 bis[2 (isopropylthio)acetamido] 9 fluorenone; 2,7 bis[2 (morpholine)acetamido] 9 fluorenone; 2,7 bis[2 (n methylpiperazino)acetamido] 9 fluorenone; 2,7 bis[2 (piperidino)acetamido] 9 fluorenone; 2,7 bis[2 (propylamino)acetamido] 9 fluorenone; 2,7 bis[2 (propylthio)acetamido] 9 fluorenone; 2,7 bis[2 (pyrrolidino)acetamido] 9 fluorenone; 2,7 bis[2 [(2 hydroxyethyl)amino]acetamido] 9 fluorenone; 2,7 bis[2 [(2 hydroxyethyl)thio]acetamido] 9 fluorenone; 2,7 bis[3 (butylamino)propionamido] 9 fluorenone; 2,7 bis[3 (ethylamino)propionamido] 9 fluorenone; 2,7 bis[3 (isobutylamino)propionamido] 9 fluorenone; 2,7 bis[3 (isopropylamino)propionamido] 9 fluorenone; 2,7 bis[3 (propylamino)propionamido] 9 fluorenone; 2,7 diamidofluorenone; 2,7 diamidofluorenone derivative; 2,7 diamino 9 fluorenone; anthraquinone derivative; antineoplastic agent; camptothecin; DNA topoisomerase inhibitor; fluorenone derivative; nsc 746364; nsc 763959; nsc 763960; nsc 763961; nsc 763962; nsc 763963; nsc 763964; nsc 763973; nsc 763974; nsc 763975; nsc 765593; unclassified drug; unindexed drug; antiproliferative activity; article; cancer cell; cancer inhibition; concentration response; controlled study; cytostasis; drug cytotoxicity; drug design; drug screening; drug synthesis; human; human cell; structure activity relation; Fluorenones; NCI 60-cell panel assay; Tilorone; Topoisomerase I; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; DNA Topoisomerases, Type I; Drug Design; Humans; Structure-Activity Relationship; Tilorone; Topoisomerase I Inhibitors | - |
| dc.subject.other | [SDGs]SDG3 | - |
| dc.title | Design, synthesis and antiproliferative evaluation of fluorenone analogs with DNA topoisomerase i inhibitory properties | en_US |
| dc.type | journal article | - |
| dc.identifier.doi | 10.1016/j.bmc.2013.09.006 | - |
| dc.identifier.pmid | 24094433 | - |
| dc.identifier.scopus | 2-s2.0-84885858566 | - |
| dc.relation.pages | 7125-7133 | - |
| dc.relation.journalvolume | 21 | - |
| dc.relation.journalissue | 22 | - |
| item.grantfulltext | none | - |
| item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
| item.openairetype | journal article | - |
| item.fulltext | no fulltext | - |
| item.cerifentitytype | Publications | - |
| crisitem.author.dept | Pharmacy | - |
| crisitem.author.dept | School of Pharmacy | - |
| crisitem.author.orcid | 0000-0002-6738-6054 | - |
| crisitem.author.parentorg | College of Medicine | - |
| crisitem.author.parentorg | College of Medicine | - |
| Appears in Collections: | 藥學系 | |
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