https://scholars.lib.ntu.edu.tw/handle/123456789/564815| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Thangaraj S. | en_US |
| dc.contributor.author | Tsao W.-S. | en_US |
| dc.contributor.author | Luo Y.-W. | en_US |
| dc.contributor.author | Lee Y.-J. | en_US |
| dc.contributor.author | Chang C.-F. | en_US |
| dc.contributor.author | Lin C.-C. | en_US |
| dc.contributor.author | Uang B.-J. | en_US |
| dc.contributor.author | Yu C.-C. | en_US |
| dc.contributor.author | JIH-HWA GUH | en_US |
| dc.contributor.author | Teng C.-M. | en_US |
| dc.date.accessioned | 2021-06-02T05:43:48Z | - |
| dc.date.available | 2021-06-02T05:43:48Z | - |
| dc.date.issued | 2011 | - |
| dc.identifier.issn | 404020 | - |
| dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-79960613881&doi=10.1016%2fj.tet.2011.06.054&partnerID=40&md5=b4eb510049bb3cc4ac55f6a21d7f9c5b | - |
| dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/564815 | - |
| dc.description.abstract | The first synthesis of moniliformediquinone has been achieved in which the longest linear sequence is only nine steps. The synthesis proceeds in 23% overall yield from commercially available 2,4,5-trimethoxybenzaldehyde. The key transformations include a Pd-catalyzed coupling between a phenyl triflate and an acetylene, and a TiCl4-mediated cyclization of a benzoquinone intermediate. In addition, in vitro inhibitory effects of moniliformediquinone, denbinobin, moscatilin, and calanquinone A were determined to have IC 50 values of 0.7, 1.6, 2.5, and 1.5 μM, respectively. ? 2011 Elsevier Ltd. All rights reserved. | - |
| dc.relation.ispartof | Tetrahedron | - |
| dc.subject | Calanquinone A; Denbinobin; Moniliformediquinone; Moscatilin; TiCl 4-mediated | - |
| dc.subject.other | 1 (2 bromo 3,5 dimethoxyphenyl) 2 (2,4,5 trimethoxyphenyl)ethane; 1 (2 iodo 3,5 dimethoxyphenyl) 2 (2,4,5 trimethoxyphenyl)ethane; 1 (3,5 dimethoxyphenyl) 2 (2,4,5 trimethoxyphenyl)ethane; 1,1 dibromo 2 (2,4,5 trimethoxyphenyl)ethene; 2,4,5 trimethoxyphenylacetylene; 3,5 diacetoxy 1 [2 (2,4,5 trimethoxyphenyl)ethynyl]benzene; 3,5 dimethoxyphenyl triflate; 5 diacetoxy 1 [2 (2,4,5 trimethoxyphenyl)ethyl]benzene; 5 methoxy 2 (2 bromo 3,5 dimethoxyphenethyl) 1,4 benzoquinone; 5 methoxy 2 (2 iodo 3,5 dimethoxyphenethyl) 1,4 benzoquinone; 5 methoxy 2 (3,5 dimethoxyphenethyl) 1,4 benzoquinone; 5',7' dimethoxy spiro(2,5 dimethoxy cyclohexa 2,5 dien 4 one 1,1' indan); 5',7' dimethoxy spiro(4 methoxy 3 cyclohexen 2,5 dione 1,1' indan); 9,10 dihydro 3,5,7 trimethoxy 1,4 phenanthrenedione; calanquinone; cis 1 (3,5 diacetoxy) 2 (2,4,5 trimethoxy)stilbene; cis 1 (3,5 dimethoxy) 2 (2,4,5 trimethoxy)stilbene; denbinobin; moniliformediquinone; moscatilin; quinone derivative; tamoxifen; unclassified drug; antineoplastic activity; article; breast cancer; cancer cell; catalysis; cyclization; drug structure; drug synthesis; herbal medicine; human; IC 50; in vitro study; medicinal plant; priority journal | - |
| dc.subject.other | [SDGs]SDG3 | - |
| dc.title | Total synthesis of moniliformediquinone and calanquinone A as potent inhibitors for breast cancer | en_US |
| dc.type | journal article | - |
| dc.identifier.doi | 10.1016/j.tet.2011.06.054 | - |
| dc.identifier.scopus | 2-s2.0-79960613881 | - |
| dc.relation.pages | 6166-6172 | - |
| dc.relation.journalvolume | 67 | - |
| dc.relation.journalissue | 34 | - |
| item.openairetype | journal article | - |
| item.fulltext | no fulltext | - |
| item.grantfulltext | none | - |
| item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
| item.cerifentitytype | Publications | - |
| crisitem.author.dept | Pharmacy | - |
| crisitem.author.dept | School of Pharmacy | - |
| crisitem.author.orcid | 0000-0002-6738-6054 | - |
| crisitem.author.parentorg | College of Medicine | - |
| crisitem.author.parentorg | College of Medicine | - |
| Appears in Collections: | 藥學系 | |
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