https://scholars.lib.ntu.edu.tw/handle/123456789/565282
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Lee H.-Y. | en_US |
dc.contributor.author | CHIA-RON YANG | en_US |
dc.contributor.author | Lai M.-J. | en_US |
dc.contributor.author | Huang H.-L. | en_US |
dc.contributor.author | Hsieh Y.-L. | en_US |
dc.contributor.author | Liu Y.-M. | en_US |
dc.contributor.author | Yeh T.-K. | en_US |
dc.contributor.author | Li Y.-H. | en_US |
dc.contributor.author | Mehndiratta S. | en_US |
dc.contributor.author | Teng C.-M. | en_US |
dc.contributor.author | Liou J.-P. | en_US |
dc.date.accessioned | 2021-06-04T08:33:27Z | - |
dc.date.available | 2021-06-04T08:33:27Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 14394227 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84879840340&doi=10.1002%2fcbic.201300201&partnerID=40&md5=b41a82d325f2bb9049b3ba42f1235042 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/565282 | - |
dc.description.abstract | A series of 1-arylsulfonyl-5-(N-hydroxyacrylamide)indolines (7-15) has been developed; the compounds exhibited potent histone deacetylase (HDAC) inhibitory activities. Notably, almost all of this series exhibited better HDAC-inhibitory and antiproliferative activities than 3-(1-benzenesulfonyl-1H-indol-5-yl)-N-hydroxyacrylamide (6), as reported in a previous study. Among these compounds, 3-[1-(4-methoxybenzenesulfonyl)-2,3-dihydro-1H-indol-5-yl]-N-hydroxyacrylamide (9) showed a two- to tenfold increase in activity compared to SAHA (1) in the suppression of lipopolysaccharide-induced cytokine production. Compound 9 also caused a marked reduction in carrageenan-induced acute inflammation in a rat model. Taken together, these data indicated that 1-arylsulfonyl-5-(N-hydroxyacrylamide)indolines HDAC inhibitors exhibit potent anti-inflammatory activity. HDAC inhibitors suppress cytokine in vitro and in vivo: A panel of HDAC inhibitors was developed and evaluated for anti-inflammatory activity, which has not been well studied previously. Compound 1 was more potent than SAHA in vitro and in vivo. Our results suggest that 1 is a novel agent for the treatment of inflammation-associated diseases. Copyright ? 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. | - |
dc.relation.ispartof | ChemBioChem | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | 3 (1 benzenesulfonyl 1h indol 5 yl) n hydroxyacrylamide; 3 [1 (4 methoxybenzenesulfonyl) 2,3 dihydro 1h indol 5 yl] n hydroxyacrylamide; antiinflammatory agent; cyclooxygenase 2; histone deacetylase inhibitor; indometacin; inducible nitric oxide synthase; interleukin 6; prostaglandin E2; tumor necrosis factor alpha; unclassified drug; vorinostat; animal experiment; animal model; antiinflammatory activity; antiproliferative activity; article; controlled study; cytokine production; cytokine release; IC 50; nonhuman; priority journal; protein expression; rat; Wittig reaction; anti-inflammatory agents; gene expression; histone deacetylase; indolines; inhibitors; Acrylamides; Animals; Anti-Inflammatory Agents; Cytokines; HeLa Cells; Histone Deacetylase Inhibitors; Humans; Indoles; Male; Mice; Rats; Rats, Wistar; Structure-Activity Relationship; Rattus | - |
dc.title | 1-Arylsulfonyl-5-(N-hydroxyacrylamide)indolines Histone Deacetylase Inhibitors Are Potent Cytokine Release Suppressors | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1002/cbic.201300201 | - |
dc.identifier.pmid | 23788254 | - |
dc.identifier.scopus | 2-s2.0-84879840340 | - |
dc.relation.pages | 1248-1254 | - |
dc.relation.journalvolume | 14 | - |
dc.relation.journalissue | 10 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Pharmacy | - |
crisitem.author.dept | School of Pharmacy | - |
crisitem.author.orcid | 0000-0001-5990-1346 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 藥學系 |
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