https://scholars.lib.ntu.edu.tw/handle/123456789/566043
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Hung, W.-L. | en_US |
dc.contributor.author | Ho, C.-T. | en_US |
dc.contributor.author | MIN-HSIUNG PAN | en_US |
dc.creator | Hung, W.-L.;Ho, C.-T.;Pan, M.-H. | - |
dc.date.accessioned | 2021-06-22T02:01:30Z | - |
dc.date.available | 2021-06-22T02:01:30Z | - |
dc.date.issued | 2020 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.url?eid=2-s2.0-85075166497&partnerID=40&md5=0212ae2fa920449d0c73970b758e86c4 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/566043 | - |
dc.description.abstract | Neurological disorders occur in the central and peripheral nervous system and include Alzheimer's disease, stroke, and spinal cord injury. Activation of the innate immune system inevitably occurs in all forms of neurological disorders. The NOD-, LRR- and pyrin domain-containing 3 (NLRP3) inflammasome is a multimolecular complex that can sense danger signals associated with neurological disorders. Assembly of the NLRP3 inflammasome promotes caspase-1-mediated interleukin-1β and interleukin-18 maturation in microglia, where neuroinflammation contributes to neurological disease development and progression. Thus, this review attempts to elucidate the current knowledge regarding NLRP3 inflammasome activation and its crucial role in the pathogenesis of neurological disorders. Recent scientific findings with respect to neuroprotective effects of dietary phytochemicals against NLRP3 inflammasome-mediated neurological disorders summarized in this review suggest that modulation of the NLRP3 inflammasome assembly by plant-derived phytochemicals could be a potential strategy for prevention or treatment of neurological disorders. ? 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim | - |
dc.relation.ispartof | Molecular Nutrition and Food Research | - |
dc.subject | dietary phytochemicals; neuroinflammation; neurological disorders; NLRP3 inflammasome | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | cryopyrin; inflammasome; phytochemical; animal; chemistry; drug effect; human; metabolism; molecularly targeted therapy; neurologic disease; Animals; Humans; Inflammasomes; Molecular Targeted Therapy; Nervous System Diseases; NLR Family, Pyrin Domain-Containing 3 Protein; Phytochemicals | - |
dc.title | Targeting the NLRP3 Inflammasome in Neuroinflammation: Health Promoting Effects of Dietary Phytochemicals in Neurological Disorders | en_US |
dc.type | review | en |
dc.identifier.doi | 10.1002/mnfr.201900550 | - |
dc.identifier.pmid | 31675164 | - |
dc.identifier.scopus | 2-s2.0-85075166497 | - |
dc.relation.journalvolume | 64 | - |
dc.relation.journalissue | 4 | - |
item.openairetype | review | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Food Science and Technology | - |
crisitem.author.orcid | 0000-0002-5188-7030 | - |
crisitem.author.parentorg | College of Bioresources and Agriculture | - |
顯示於: | 食品科技研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。