https://scholars.lib.ntu.edu.tw/handle/123456789/566397
標題: | Clinical and epidemiological characteristics in hospitalized young children with acute gastroenteritis in southern Taiwan: According to major pathogens | 作者: | Chung N. Wang S.-M. Shen C.-F. Kuo F.-C. Ho T.-S. Hsiung C.A. Mu J.-J. Wu F.-T. LI-MIN HUANG Huang Y.-C. Huang Y.-C. Chi H. Lin H.-C. Liu C.-C. Taiwan Pediatric Infectious Disease Alliance |
關鍵字: | Acute gastroenteritis; Children; Epidemiology; Taiwan | 公開日期: | 2017 | 出版社: | Elsevier Ltd | 卷: | 50 | 期: | 6 | 起(迄)頁: | 915-922 | 來源出版物: | Journal of Microbiology, Immunology and Infection | 摘要: | Background Acute gastroenteritis (AGE) can be caused by a wide array of pathogens, including bacteria, viruses, and parasites. A prospective study to investigate the epidemiology and clinical presentation in young children hospitalized with AGE was conducted in a medical center in southern Taiwan. Methods Patients aged less than 5 years who was hospitalized due to AGE in National Cheng Kung University Hospital were enrolled from July 2014 to June 2016. The demographic information, clinical features and laboratory data were collected by chart reviews, and stool samples were sent to Centers of Disease Control, Taiwan (Taiwan CDC) for a panel of pathogen identification consisting of two viruses, nine bacteria, and five parasites. Results Totally 441 patients were enrolled in this study. Salmonella spp. was the leading cause of disease (21.8%), followed by norovirus (17.0%), Clostridium difficile (9.5%), and rotavirus (9.3%). Norovirus identification rate was the highest among patients less than 6 months of age, while Salmonella was highest among patients between 2 and 3 years old. Patients with Salmonella infection frequently presented with fever, lethargy, bloody stool, and elevated serum level of C-reactive protein (CRP); norovirus and rotavirus infection frequently presented with vomiting. Salmonella gastroenteritis also resulted in longer hospitalization and more frequent antibiotics administration. C. difficile could be isolated from both gastroenteritis patients and control children. Conclusion Salmonella spp. was the most common pathogen of AGE in hospitalized children in southern Taiwan during 2014–2016, followed by norovirus and rotavirus. Further monitoring of epidemiology characteristics among cardinal pathogens of pediatric gastroenteritis is necessary. ? 2017 |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85028636409&doi=10.1016%2fj.jmii.2017.07.015&partnerID=40&md5=188bca3ac390088825c8c54e788db070 https://scholars.lib.ntu.edu.tw/handle/123456789/566397 |
ISSN: | 1684-1182 | DOI: | 10.1016/j.jmii.2017.07.015 | SDG/關鍵字: | antibiotic agent; C reactive protein; Rotavirus vaccine; acute gastroenteritis; Article; bacterium isolation; child; clinical feature; disease course; female; fever; hospitalized child; human; infant; length of stay; lethargy; major clinical study; male; nonhuman; Norovirus; Peptoclostridium difficile; preschool child; prospective study; rectum hemorrhage; Rotavirus; Salmonella; Taiwan; treatment outcome; virus identification; vomiting; calicivirus infection; feces; gastroenteritis; isolation and purification; microbiology; pathology; Rotavirus infection; salmonellosis; Caliciviridae Infections; Child, Preschool; Clostridium difficile; Feces; Female; Gastroenteritis; Humans; Infant; Male; Norovirus; Prospective Studies; Rotavirus; Rotavirus Infections; Salmonella; Salmonella Infections; Taiwan; Treatment Outcome |
顯示於: | 醫學系 |
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