https://scholars.lib.ntu.edu.tw/handle/123456789/567729
標題: | Inflammasomes and Childhood Autoimmune Diseases: A Review of Current Knowledge | 作者: | Yang C.-A. BOR-LUEN CHIANG |
關鍵字: | Autoimmunity; Autoinflammation; Inflammasome; Pathogen-associated molecular patterns; Pediatric rheumatic disease | 公開日期: | 2020 | 出版社: | Springer | 來源出版物: | Clinical Reviews in Allergy and Immunology | 摘要: | Inflammasomes are multiprotein complexes capable of sensing pathogen-associated molecular patterns (PAMPs), danger-associated molecular patterns (DAMPs), and cellular perturbations. Upon stimulation, the inflammasomes activate the production of the pro-inflammatory cytokines IL-1β and IL-18 and induce gasdermin D-mediated pyroptosis. Dysregulated inflammasome signaling could lead to hyperinflammation in response to environmental triggers, thus contributing to the pathogenesis of childhood autoimmune/autoinflammatory diseases. In this review, we group childhood rheumatic diseases into the autoinflammation to autoimmunity spectrum and discuss about the involvement of inflammasomes in disease mechanisms. Genetic mutations in inflammasome components cause monogenic autoinflammatory diseases, while inflammasome-related genetic variants have been implicated in polygenic childhood rheumatic diseases. We highlight the reported associations of inflammasome signaling-related genetic polymorphisms/protein levels with pediatric autoimmune disease susceptibility and disease course. Furthermore, we discuss about the use of IL-1 receptor antagonist as an adjunctive therapy in several childhood autoimmune diseases, including macrophage activation syndrome (MAS) and multisystem inflammatory syndrome in children (MIS-C) related to COVID-19. A comprehensive multi-cohort comparison on inflammasome gene expression profile in different pediatric rheumatic diseases is needed to identify patient subsets that might benefit from the adjunctive therapy of IL-1β inhibitors. ? 2020, Springer Science+Business Media, LLC, part of Springer Nature. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85096466471&doi=10.1007%2fs12016-020-08825-2&partnerID=40&md5=4e577f37b0c832968b5eda9bd41a9e5a https://scholars.lib.ntu.edu.tw/handle/123456789/567729 |
ISSN: | 1080-0549 | DOI: | 10.1007/s12016-020-08825-2 | SDG/關鍵字: | cytokine; inflammasome; animal; autoimmune disease; autoimmunity; child; genetics; human; metabolism; mutation; rheumatic disease; signal transduction; Animals; Autoimmune Diseases; Autoimmunity; Child; Cytokines; Humans; Inflammasomes; Mutation; Rheumatic Diseases; Signal Transduction |
顯示於: | 醫學系 |
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