https://scholars.lib.ntu.edu.tw/handle/123456789/567920
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Lee C.-C. | en_US |
dc.contributor.author | BOR-LUEN CHIANG | en_US |
dc.date.accessioned | 2021-07-02T03:42:05Z | - |
dc.date.available | 2021-07-02T03:42:05Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 1566-5232 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-54749147546&doi=10.2174%2f156652308785160692&partnerID=40&md5=f7dd2082837309c71993b761a82b2054 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/567920 | - |
dc.description.abstract | Since the RNAi mechanisms were established in 1990, the rapid progression of RNAi application from animal to clinical trails in human diseases has shown its enormous therapeutic potential. In this review, RNAi therapeutics in allergic diseases is discussed, from RNAi mechanisms and design to challenges and potential targets in allergic diseases. Current reported studies on investigating RNAi therapy in vitro and in vivo are also reviewed. Although there are promising studies in RNAi-based therapy, understanding further the detailed mechanisms of RNAi-based therapy and investigating more effective delivery methods are required for future development. ? 2008 Bentham Science Publishers Ltd. | - |
dc.relation.ispartof | Current Gene Therapy | - |
dc.subject | Allergy; Cytokine; Gene therapy; RNAi; shRNA; siRNA; Susceptibility genes; Transcription factor | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | adenovirus vector; double stranded RNA; eotaxin; intercellular adhesion molecule 1 antibody; interleukin 13; interleukin 4; interleukin 4 receptor alpha; interleukin 5; lentivirus vector; microRNA; parvovirus vector; short hairpin RNA; small interfering RNA; STAT6 protein; toll like receptor; transcription factor GATA 3; very late activation antigen 4; virus vector; allergic disease; asthma; Crohn disease; cytokine production; cytokine release; drug mechanism; drug potency; gene expression; gene expression regulation; gene silencing; gene targeting; genetic susceptibility; genetic transfection; human; Human immunodeficiency virus infection; liposomal gene delivery system; low drug dose; nonhuman; nonviral gene therapy; review; RNA interference; single nucleotide polymorphism; Th2 cell; transcription initiation; viral gene delivery system; Animals; Humans; Hypersensitivity; MicroRNAs; RNA Interference; RNA, Small Interfering; Animalia | - |
dc.title | RNA interference: New therapeutics in allergic diseases | en_US |
dc.type | Review | en |
dc.identifier.doi | 10.2174/156652308785160692 | - |
dc.identifier.pmid | 18691019 | - |
dc.identifier.scopus | 2-s2.0-54749147546 | - |
dc.relation.pages | 236-246 | - |
dc.relation.journalvolume | 8 | - |
dc.relation.journalissue | 4 | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | Review | - |
item.grantfulltext | none | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Clinical Medicine | - |
crisitem.author.dept | Oral Biology | - |
crisitem.author.dept | College of Life Science | - |
crisitem.author.dept | Immunology | - |
crisitem.author.orcid | 0000-0002-6705-0286 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 醫學系 |
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