https://scholars.lib.ntu.edu.tw/handle/123456789/567952
Title: | Infectious pathogens in pediatric patients with primary immunodeficiencies | Authors: | Chang S.-H. YAO-HSU YANG BOR-LUEN CHIANG |
Issue Date: | 2006 | Journal Volume: | 39 | Journal Issue: | 6 | Start page/Pages: | 503-515 | Source: | Journal of Microbiology, Immunology and Infection | Abstract: | Background and Purpose: Primary immunodeficiency diseases (PIDs) are rare disorders. Unusual infections often guide the initial investigation for immunodeficiency. Methods: In order to ascertain the organisms that lead to a predisposition for PIDs, we reviewed the charts of 92 children diagnosed with PIDs at the National Taiwan University Hospital between March 1984 and March 2004. Results: Pneumonia was diagnosed in 92%, 81%, and 76.5% of patients with antibody, combined, and cellular deficiencies, respectively. Other major illnesses were similar in the 3 groups and included bronchiolitis, acute gastroenteritis, otitis media, and bacteremia. Skin abscess, pneumonia, and lymphadenitis (54.5%, 45%, and 27% of cases, respectively) were the most common infections in patients with phagocyte defects. Organisms were speciated in only 44.8% of infection episodes. Most viral infections were diagnosed by traditional and time-consuming viral culture. Prophylactic antibiotics were prescribed to 9 out of the 92 patients with PIDs. Conclusions: Early recognition of PIDs requires that practitioners be aware of the infection characteristics, and subsequent reliable and rapid molecular diagnosis are needed in such immunocompromised patients. ? 2006 Journal of Microbiology, Immunology and Infection. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-33847730309&partnerID=40&md5=c9d828ccde57390f113641157df3d734 https://scholars.lib.ntu.edu.tw/handle/123456789/567952 |
ISSN: | 1684-1182 | SDG/Keyword: | amoxicillin plus clavulanic acid; antibiotic agent; cefalexin; cefixime; cefpodoxime proxetil; acute gastroenteritis; article; bacteremia; bronchiolitis; child; clinical evaluation; controlled study; human; immune deficiency; infant; infection; lymphadenitis; major clinical study; medical record; microbial identification; otitis media; phagocyte; pneumonia; prevalence; skin abscess; university hospital; communicable disease; epidemiology; immune deficiency; microbiology; newborn; pathology; pathophysiology; preschool child; retrospective study; Taiwan; teaching hospital; Causality; Child; Child, Preschool; Communicable Diseases; Hospitals, Teaching; Humans; Immunologic Deficiency Syndromes; Infant; Infant, Newborn; Phagocytes; Retrospective Studies; Taiwan |
Appears in Collections: | 醫學系 |
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