https://scholars.lib.ntu.edu.tw/handle/123456789/568400
Title: | Gender disparity in chronic hepatitis B: Mechanisms of sex hormones | Authors: | Wang S.-H. PEI-JER CHEN Shiou-Hwei Yeh |
Keywords: | Androgen; Androgen receptor; Estrogen; Estrogen receptor α; Hepatitis B virus | Issue Date: | 2015 | Publisher: | Blackwell Publishing | Journal Volume: | 30 | Journal Issue: | 8 | Start page/Pages: | 1237-1245 | Source: | Journal of Gastroenterology and Hepatology (Australia) | Abstract: | Hepatitis B virus (HBV) is a common human pathogen transmitted worldwide, and its chronic infection is a well-known risk factor for hepatocellular carcinoma (HCC). The sex disparity of HBV-related liver diseases has been noticed for a long time, which could be attributed to sex hormone effects, other than gender behaviors or environmental impact. This difference is experimentally confirmed in HBV transgenic mice, as well as in immunocompetent mice receiving hydrodynamic delivery of HBV. Androgen and estrogen pathways were identified to play opposite regulations of HBV transcription by targeting viral enhancer I at molecular level. In addition to the direct effects on HBV life cycle, sex hormones may be also involved in the immune response to HBV infection and the progression of associated liver diseases, although the detailed mechanisms are still unclear. Besides, several unaddressed issues such as HBV entry, microRNA profiles, viral integration, and adaptability in which androgen and estrogen axes might be involved are warranted to be delineated. The comprehensive understanding of the sex disparity in HBV virology and pathogenesis will be helpful to provide newly biomarkers for clinical diagnosis and develop novel drugs to manage HBV-related HCC patients. ? 2015 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84937406883&doi=10.1111%2fjgh.12934&partnerID=40&md5=4bf880f6f72c3862fd926b6097151090 https://scholars.lib.ntu.edu.tw/handle/123456789/568400 |
ISSN: | 0815-9319 | DOI: | 10.1111/jgh.12934 | SDG/Keyword: | androgen; biological marker; estrogen; microRNA; sex hormone; virus RNA; androgen; estrogen; chronic disease; chronic hepatitis B; disease course; human; immune response; liver disease; nonhuman; pathogenesis; priority journal; Review; sex difference; virology; virus DNA cell DNA interaction; virus entry; virus transcription; animal; Carcinoma, Hepatocellular; complication; female; genetic transcription; genetics; hepatitis B; Hepatitis B virus; immunology; Liver Neoplasms; male; physiology; risk factor; sexual development; signal transduction; transgenic mouse; Androgens; Animals; Carcinoma, Hepatocellular; Estrogens; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver Neoplasms; Male; Mice, Transgenic; MicroRNAs; Risk Factors; Sex Characteristics; Signal Transduction; Transcription, Genetic; Virus Integration |
Appears in Collections: | 臨床醫學研究所 |
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