https://scholars.lib.ntu.edu.tw/handle/123456789/568572
Title: | The ratio of aminotransferase to platelets is a useful index for predicting hepatic fibrosis in hemodialysis patients with chronic hepatitis C | Authors: | CHEN-HUA LIU Liang C.-C. CHUN-JEN LIU SHIH-JER HSU JOU-WEI LIN Chen S.-I. Hung P.-H. Tsai H.-B. Lai M.-Y. PEI-JER CHEN Chen J.-H. DING-SHINN CHEN JIA-HORNG KAO |
Issue Date: | 2010 | Publisher: | Nature Publishing Group | Journal Volume: | 78 | Journal Issue: | 1 | Start page/Pages: | 103-109 | Source: | Kidney International | Abstract: | Percutaneous liver biopsy is the gold standard for staging hepatic fibrosis of hemodialysis patients with chronic hepatitis C before renal transplantation or antiviral therapy. Concerns exist, however, about serious post-biopsy complications. To evaluate a more simple approach using standard laboratory tests to predict hepatic fibrosis and its evolution, we studied 279 consecutive hemodialysis patients with chronic hepatitis C and a baseline biopsy. Among them, 175 receiving antiviral therapy underwent follow-up biopsy to evaluate the histological evolution of fibrosis. Multivariate analysis of routine laboratory tests at baseline showed the aspartate aminotransferase-to-platelet ratio index was an independent predictor of significant hepatic fibrosis. The areas under curves of this ratio to predict fibrosis stages F2-4 were 0.83 and 0.71 in the baseline and follow-up sets; and 0.75 and 0.80 respectively, for patients with sustained or non-sustained virological response groups in the follow-up sets. By a judicious setting of cut-off levels for the baseline and non-sustained groups, and the sustained virological response group, almost half and 60 percent of the baseline and follow-up sets could be correctly diagnosed without biopsy. Our study found the aminotransferase-to-platelet ratio index is accurate and reproducible for assessing hepatic fibrosis in hemodialysis patients with chronic hepatitis C. Applying this simple index could decrease the need of percutaneous liver biopsy in this clinical setting. ? 2010 International Society of Nephrology. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-77953655149&doi=10.1038%2fki.2010.74&partnerID=40&md5=25c2e9886bdd9ec470f9d9bc4996a30d https://scholars.lib.ntu.edu.tw/handle/123456789/568572 |
ISSN: | 0085-2538 | DOI: | 10.1038/ki.2010.74 | SDG/Keyword: | aminotransferase; antivirus agent; aminotransferase; aspartate aminotransferase; adult; antiviral therapy; article; chronic hepatitis; clinical evaluation; controlled study; female; follow up; hemodialysis; hepatitis C; Hepatitis C virus; histopathology; human; laboratory test; liver biopsy; liver fibrosis; major clinical study; male; priority journal; prognosis; biopsy; complication; diagnostic use; Hepatitis C, Chronic; liver cirrhosis; middle aged; needle biopsy; pathology; renal replacement therapy; thrombocyte; thrombocyte count; Adult; Aspartate Aminotransferases; Biopsy; Biopsy, Needle; Blood Platelets; Female; Hepatitis C, Chronic; Humans; Liver Cirrhosis; Male; Middle Aged; Platelet Count; Renal Dialysis; Transaminases |
Appears in Collections: | 臨床醫學研究所 |
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