https://scholars.lib.ntu.edu.tw/handle/123456789/568786
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Wang, Jin-Town | en_US |
dc.contributor.author | Lee, Cha-Ze | en_US |
dc.contributor.author | PEI-JER CHEN | en_US |
dc.contributor.author | Wang T-.H. | en_US |
dc.contributor.author | DING-SHINN CHEN | en_US |
dc.date.accessioned | 2021-07-03T03:35:49Z | - |
dc.date.available | 2021-07-03T03:35:49Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 0041-1132 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84983726669&doi=10.1046%2fj.1537-2995.2002.00274.x&partnerID=40&md5=c4e50d54922025109820194370797168 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/568786 | - |
dc.description.abstract | BACKGROUND: By NAT, HBV DNA is occasionally detectable in blood donors with past HBV infection but negative for HBsAg. Whether or not these donors can cause transfusion-transmitted HBV infections is uncertain. STUDY DESIGN AND METHODS: To determine whether or not donors with past HBV infection but negative for HbsAg can cause HBV transfusion-transmitted infections, recipients followed for blood transfusion in a university medical center in Taiwan were studied. HBV DNA and serologic markers were tested in donors and recipients. RESULTS: Of 1,038 enrolled recipients, 910 completed the 6-month post-transfusion follow-up visit. Of these, only 39 patients (4.3%) tested negative on the pretransfusion sample for HBsAg, anti-HBs, anti-HBc, and HBV DNA by PCR. These 39 HBV-naive recipients had been transfused with blood from 147 donations for which stored samples were available for HBV DNA testing by PCR; 11 of these HBsAg-negative samples tested positive for HBV DNA and anti-HBc. Two of the 11 patients who received the HBV-DNA-positive donations (18%) became positive for HBV DNA, and one seroconverted to anti-HBc and finally to anti-HBs, with a mild transient elevation of serum ALT activities. Based on the one confirmed case of HBV transmission, a projection was made that approximately 200 post-transfusion HBV infections could occur in one million units of transfused blood in Taiwan. CONCLUSIONS: In HBV-endemic areas like Taiwan, where blood donors are screened for HBsAg only, the risk of transfusion-transmitted HBV appears to be substantial. Implementation of NAT for blood screening in these settings warrants consideration. | en_US |
dc.relation.ispartof | Transfusion | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | hepatitis B surface antigen; virus antibody; virus antigen; virus DNA; article; blood; blood donor; blood transfusion; disease transmission; DNA sequence; endemic disease; follow up; hepatitis B; Hepatitis B virus; human; immunology; molecular genetics; prospective study; Taiwan; Antibodies, Viral; Antigens, Viral; Blood Donors; Blood Transfusion; DNA, Viral; Endemic Diseases; Follow-Up Studies; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Molecular Sequence Data; Prospective Studies; Sequence Analysis, DNA; Taiwan | - |
dc.title | Transfusion-transmitted HBV infection in an endemic area: The necessity of more sensitive screening for HBV carriers | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1046/j.1537-2995.2002.00274.x | - |
dc.identifier.pmid | 12473140 | - |
dc.identifier.scopus | 2-s2.0-84983726669 | - |
dc.relation.pages | 1592-1597 | en_US |
dc.relation.journalvolume | 42 | en_US |
dc.relation.journalissue | 12 | en_US |
item.fulltext | no fulltext | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.openairetype | journal article | - |
crisitem.author.dept | Microbiology | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Clinical Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0002-1595-6801 | - |
crisitem.author.orcid | 0000-0002-0974-3527 | - |
crisitem.author.orcid | 0000-0001-8316-3785 | - |
crisitem.author.orcid | 0000-0001-7791-6154 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 臨床醫學研究所 |
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