https://scholars.lib.ntu.edu.tw/handle/123456789/568899
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Tsai S.-L. | en_US |
dc.contributor.author | PEI-JER CHEN | en_US |
dc.contributor.author | Hwang L.-H. | en_US |
dc.contributor.author | JIA-HORNG KAO | en_US |
dc.contributor.author | Huang J.-H. | en_US |
dc.contributor.author | Chang T.-H. | en_US |
dc.contributor.author | Chen D.-S. | en_US |
dc.date.accessioned | 2021-07-03T03:36:21Z | - |
dc.date.available | 2021-07-03T03:36:21Z | - |
dc.date.issued | 1994 | - |
dc.identifier.issn | 0168-8278 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028067268&doi=10.1016%2fS0168-8278%2805%2980320-4&partnerID=40&md5=56e0117207bcf7d80a9b382aaa1914a7 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/568899 | - |
dc.description.abstract | The immune responses to a hepatitis C virus nonstructural protein (T3Ag) overlapping with the C100-3 antigen were examined in three groups of patients with chronic non-A, non-B hepatitis. Group I included 20 cases positive for both anti-C100-3 and the second-generation anti-HCV test (anti-HCV-II); Group II, five cases with anti-C100-3(-)/anti-HCV-II(+); and Group III, seven cases negative for both tests. HCV RNA was detectable in 20 (100%), 4 (80%) and 0 (0%) patients in each group, respectively. Proliferative responses of peripheral blood mononuclear cells to T3Ag were present in 16 (80%), 3 (60%) and 0 (0%) cases in each group, respectively (p<0.05). Removal of CD8+ T cells from peripheral blood mononuclear cells resulted in a conversion of unresponsiveness to significant proliferation to T3Ag in the remaining cases in groups I and II, but not in group III. This change paralleled the antigen-induced production of interferon-γ and interleukin-2, but not interleukin-4. The removal also enhanced the T3Ag-stimulated anti-C100-3 antibody production from cultured peripheral blood mononuclear cells in group II patients. These results indicate that the T3Ag-specific type 1 T helper cells play an important role in regulating anti-C100-3 antibody secretion in hepatitis C patients. ? 1994 Journal of Hepatology. | - |
dc.relation.ispartof | Journal of Hepatology | - |
dc.subject | Anti-C100-3 antibody; Hepatitis C virus; Non-structural protein; Type 1 T helper cell | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | gamma interferon; interleukin 2; virus antibody; virus protein; adult; aged; antibody production; article; clinical article; controlled study; female; helper cell; hepatitis c; hepatitis c virus; human; immune response; male; priority journal; Adult; Aged; Antigens, Viral; Base Sequence; Cells, Cultured; Chronic Disease; DNA, Viral; Female; Hepacivirus; Hepatitis Antibodies; Hepatitis C; Hepatitis C Antibodies; Human; Interferon Type II; Interleukin-2; Interleukin-4; Leukocytes, Mononuclear; Male; Middle Age; Molecular Sequence Data; Polymerase Chain Reaction; Recombinant Proteins; RNA, Viral; Support, Non-U.S. Gov't; Viral Nonstructural Proteins | - |
dc.title | Immune response to a hepatitis C virus nonstructural protein in chronic hepatitis C virus infection | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/S0168-8278(05)80320-4 | - |
dc.identifier.pmid | 7530738 | - |
dc.identifier.scopus | 2-s2.0-0028067268 | - |
dc.relation.pages | 403-411 | - |
dc.relation.journalvolume | 21 | - |
dc.relation.journalissue | 3 | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Clinical Medicine | - |
crisitem.author.dept | Clinical Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0001-8316-3785 | - |
crisitem.author.orcid | 0000-0002-2442-7952 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 臨床醫學研究所 |
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