https://scholars.lib.ntu.edu.tw/handle/123456789/569126
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | HUI-HSIN KO | en_US |
dc.contributor.author | Peng H.-H. | en_US |
dc.contributor.author | SHIH-JUNG CHENG | en_US |
dc.contributor.author | YEN-PING KUO | en_US |
dc.date.accessioned | 2021-07-05T05:41:52Z | - |
dc.date.available | 2021-07-05T05:41:52Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1043-3074 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85056484256&doi=10.1002%2fhed.25370&partnerID=40&md5=14a08135c36adfea6190cb749c511afd | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/569126 | - |
dc.description.abstract | Background: Aldo-keto reductase family 1 member B10 (AKR1B10) expression in oral squamous cell carcinoma (OSCC) tissue specimens is correlated with the progression and prognosis of OSCC. Methods: Saliva samples were obtained from 35 normal controls and 86 patients with OSCC before cancer surgery. The AKR1B10 levels were determined using enzyme-linked immunosorbent assay (ELISA). Results: The mean salivary AKR1B10 levels were significantly higher in the patients with OSCC than in the normal controls (P <.001). Higher salivary AKR1B10 levels were significantly associated with larger tumor size, more advanced clinical stage, and areca quid chewing habit. Patients with OSCC with a higher salivary AKR1B10 level (>646 pg/mL) had a significantly poorer survival than those with a lower (?646 pg/mL) salivary AKR1B10 level (P =.026). Conclusion: The salivary AKR1B10 level may be a promising biomarker for screening high-risk patients with OSCC and monitoring the progression of OSCC. ? 2018 Wiley Periodicals, Inc. | en_US |
dc.publisher | John Wiley and Sons Inc. | en_US |
dc.relation.ispartof | Head and Neck | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | aldo keto reductase family 1 member B10; biological marker; AKR1B10 protein, human; aldo keto reductase; tumor marker; adult; areca quid; Article; cancer growth; cancer prognosis; cancer staging; cancer surgery; controlled study; eating habit; enzyme linked immunospot assay; female; human; major clinical study; male; mastication; middle aged; mouth squamous cell carcinoma; priority journal; protein expression; saliva analysis; salivation; survival; tumor volume; chemistry; disease exacerbation; early cancer diagnosis; Kaplan Meier method; mortality; mouth tumor; pathology; procedures; prognosis; saliva; squamous cell carcinoma; Adult; Aldo-Keto Reductases; Biomarkers, Tumor; Carcinoma, Squamous Cell; Disease Progression; Early Detection of Cancer; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Mouth Neoplasms; Prognosis; Saliva | - |
dc.title | Increased salivary AKR1B10 level: Association with progression and poor prognosis of oral squamous cell carcinoma | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1002/hed.25370 | - |
dc.identifier.pmid | 30430672 | - |
dc.identifier.scopus | 2-s2.0-85056484256 | - |
dc.relation.pages | 2642-2647 | en_US |
dc.relation.journalvolume | 40 | en_US |
dc.relation.journalissue | 12 | en_US |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | School of Dentistry | - |
crisitem.author.dept | Dentistry | - |
crisitem.author.dept | Dentistry-NTUH | - |
crisitem.author.dept | Oral Biology | - |
crisitem.author.dept | School of Dentistry | - |
crisitem.author.dept | Dentistry-NTUH | - |
crisitem.author.dept | Dentistry | - |
crisitem.author.dept | School of Dentistry | - |
crisitem.author.dept | Dentistry-NTUH | - |
crisitem.author.orcid | 0000-0002-2024-3865 | - |
crisitem.author.orcid | 0000-0003-4674-4892 | - |
crisitem.author.orcid | 0000-0001-8321-2575 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 牙醫學系 |
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