https://scholars.lib.ntu.edu.tw/handle/123456789/569161
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | SHIH-JUNG CHENG | en_US |
dc.contributor.author | HUI-HSIN KO | en_US |
dc.contributor.author | Cheng S.-L. | en_US |
dc.contributor.author | JANG-JAER LEE | en_US |
dc.contributor.author | HSIN-MING CHEN | en_US |
dc.contributor.author | HAO-HUENG CHANG | en_US |
dc.contributor.author | SANG-HENG KOK | en_US |
dc.contributor.author | YEN-PING KUO | en_US |
dc.contributor.author | CHUN-PIN CHIANG | en_US |
dc.date.accessioned | 2021-07-05T05:42:04Z | - |
dc.date.available | 2021-07-05T05:42:04Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1354-523X | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84883798297&doi=10.1111%2fodi.12034&partnerID=40&md5=a9a36de7be3dd9b4cffe40b00f92b501 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/569161 | - |
dc.description.abstract | Objective: Placenta growth factor (PlGF) is associated with the progression and prognosis of oral cancer. Materials and methods: This study used ELISA, quantitative polymerase chain reaction, and Western blotting to study the arecoline-stimulated (PlGF) protein or mRNAexpression inhuman gingival epithelial S-G cells. Results: Arecoline, a major areca nut alkaloid and an oral carcinogen, could stimulate PlGF protein synthesis in S-G cells in a dose- and time-dependent manner. The levels of PlGF protein secretion increased about 3.1-and 3.8-fold after 24-h exposure to 0.4 and 0.8 mM arecoline, respectively. Pretreatment with antioxidant N-acetyl-L-cysteine (NAC) and ERK inhibitor PD98059, but not NF-κB inhibitor Bay 11-7082, JNK inhibitor SP600125, p38 MAPK inhibitor SB203580, and PI3-K inhibitor LY294002, significantly reduced arecolineinduced PlGF protein synthesis. ELISA analyses demonstrated that NAC and PD98059 reduced about 43% and 38% of the arecoline-induced PlGF protein secretion, respectively. However, combined treatment with NAC and PD98059 did not show additive effect. Moreover, 10 μM curcumin and 4 mM NAC significantly inhibited arecoline-induced ERK activation. Furthermore, 10 lM curcumin completely blocked arecoline-induced PlGF mRNA expression. CONCLUSION: Arecoline-induced PlGF synthesis is probably mediated by reactive oxygen species/ERK pathways, and curcumin may be an useful agent in controlling oral carcinogenesis. ? 2012 John Wiley & Sons A/S. | en_US |
dc.relation.ispartof | Oral Diseases | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | 2 (2 amino 3 methoxyphenyl)chromone; 2 morpholino 8 phenylchromone; 3 (4 methylphenylsulfonyl) 2 propenenitrile; 4 (4 fluorophenyl) 2 (4 methylsulfinylphenyl) 5 (4 pyridyl)imidazole; acetylcysteine; anthra[1,9 cd]pyrazol 6(2h) one; arecoline; curcumin; messenger RNA; placental growth factor; arecoline; curcumin; placenta protein; placental growth factor; article; betel nut; controlled study; dose response; enzyme linked immunosorbent assay; epithelium cell; gene expression; gingiva; human; human cell; mastication; mouth cancer; polymerase chain reaction; premedication; priority journal; protein expression; protein secretion; protein synthesis; quantitative analysis; signal transduction; Western blotting; antagonists and inhibitors; biosynthesis; cell culture; cytology; drug effects; metabolism; Arecoline; Cells, Cultured; Curcumin; Epithelial Cells; Gingiva; Humans; Pregnancy Proteins | - |
dc.title | Arecoline-stimulated placenta growth factor production in gingival epithelial cells: Modulation by curcumin | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1111/odi.12034 | - |
dc.identifier.pmid | 23163860 | - |
dc.identifier.scopus | 2-s2.0-84883798297 | - |
dc.relation.pages | 513-518 | en_US |
dc.relation.journalvolume | 19 | en_US |
dc.relation.journalissue | 5 | en_US |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Oral Biology | - |
crisitem.author.dept | School of Dentistry | - |
crisitem.author.dept | Dentistry-NTUH | - |
crisitem.author.dept | School of Dentistry | - |
crisitem.author.dept | Dentistry | - |
crisitem.author.dept | Dentistry-NTUH | - |
crisitem.author.dept | Dentistry | - |
crisitem.author.dept | Dentistry-NTUH | - |
crisitem.author.dept | School of Dentistry | - |
crisitem.author.dept | Dentistry | - |
crisitem.author.dept | School of Dentistry | - |
crisitem.author.dept | Dentistry-NTUH | - |
crisitem.author.dept | School of Dentistry | - |
crisitem.author.dept | Dentistry | - |
crisitem.author.dept | Dentistry-NTUH | - |
crisitem.author.dept | Dentistry | - |
crisitem.author.dept | School of Dentistry | - |
crisitem.author.dept | Dentistry-NTUH | - |
crisitem.author.dept | Dentistry | - |
crisitem.author.dept | School of Dentistry | - |
crisitem.author.dept | Dentistry-NTUH | - |
crisitem.author.dept | Oral Biology | - |
crisitem.author.orcid | 0000-0003-4674-4892 | - |
crisitem.author.orcid | 0000-0002-2024-3865 | - |
crisitem.author.orcid | 0000-0003-0964-0840 | - |
crisitem.author.orcid | 0000-0002-6118-1234 | - |
crisitem.author.orcid | 0000-0003-3372-0699 | - |
crisitem.author.orcid | 0000-0001-6445-8852 | - |
crisitem.author.orcid | 0000-0001-8321-2575 | - |
crisitem.author.orcid | 0000-0002-6190-7162 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 牙醫學系 |
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