https://scholars.lib.ntu.edu.tw/handle/123456789/569174
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | JANG-JAER LEE | en_US |
dc.contributor.author | Chang Y.-L. | en_US |
dc.contributor.author | Lai W.-L. | en_US |
dc.contributor.author | JENG-YUH KO | en_US |
dc.contributor.author | YEN-PING KUO | en_US |
dc.contributor.author | CHUN-PIN CHIANG | en_US |
dc.contributor.author | Azuma M. | en_US |
dc.contributor.author | Chen C.-W. | en_US |
dc.contributor.author | JEAN-SAN CHIA | en_US |
dc.date.accessioned | 2021-07-05T05:42:08Z | - |
dc.date.available | 2021-07-05T05:42:08Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1043-3074 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-80051765765&doi=10.1002%2fhed.21607&partnerID=40&md5=882d9cc6fe0ea57896dca1c73e056e0f | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/569174 | - |
dc.description.abstract | Background. T helper 17 (Th17) and regulatory T cells share plasticity in the expression of interleukin (IL)-17 and forkhead box P3 (FOXP3), but their mutual presence in human diseases is unclear. Methods. IL-17 and FOXP3 were analyzed by immunohistostaining and flow cytometry. The cytokine milieu was analyzed by quantitative reverse transcriptase-polymerase chain reaction (RT-PCR). Results. Oral squamous cell carcinoma expresses high levels of IL-1β, IL-6, and transforming growth factor (TGF)-β. A unique subset of FOXP3 + IL-17-producing CD4 + T cells was consistently identified in tumor-infiltrating lymphocytes from advanced stages of cancer, but not in the circulation, at a frequency of 0.5% to 5.5 % of total CD4 + T and positively correlated with the frequency of IL-17 +FOXP3 - T cells. The IL-17 +FOXP3 + T cells express CCR6 and suppress the proliferation of autologous CD4 + CD25 - responder T-cells in vitro. Conclusions. The prevalence of IL-17-producing FOXP3 + CD4 + tumor infiltrating lymphocytes is increased in oral squamous cell carcinoma. ? 2010 Wiley Periodicals, Inc. Head Neck, 2010 Copyright ? 2010 Wiley Periodicals, Inc. | en_US |
dc.relation.ispartof | Head and Neck | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | chemokine receptor CCR6; interleukin 17; interleukin 1beta; interleukin 6; transcription factor FOXP3; transforming growth factor beta; adult; aged; article; cancer staging; CD25+ T lymphocyte; CD4+ T lymphocyte; clinical article; controlled study; female; flow cytometry; gingiva; human; human cell; human tissue; immunohistochemistry; lymphocyte proliferation; male; mouth carcinoma; prevalence; priority journal; protein analysis; reverse transcription polymerase chain reaction; squamous cell carcinoma; tumor associated leukocyte; Adult; Aged; Carcinoma, Squamous Cell; Case-Control Studies; CD4-Positive T-Lymphocytes; Female; Flow Cytometry; Forkhead Transcription Factors; Humans; Immunohistochemistry; Interleukin-17; Interleukin-1beta; Interleukin-6; Lymphocytes, Tumor-Infiltrating; Male; Middle Aged; Mouth Neoplasms; Prevalence; Receptors, CCR6; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transforming Growth Factor beta | - |
dc.title | Increased prevalence of interleukin-17-producing CD4 + tumor infiltrating lymphocytes in human oral squamous cell carcinoma | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1002/hed.21607 | - |
dc.identifier.pmid | 21837700 | - |
dc.identifier.scopus | 2-s2.0-80051765765 | - |
dc.relation.pages | 1301-1308 | en_US |
dc.relation.journalvolume | 33 | en_US |
dc.relation.journalissue | 9 | en_US |
item.fulltext | no fulltext | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Dentistry | - |
crisitem.author.dept | Dentistry-NTUH | - |
crisitem.author.dept | School of Dentistry | - |
crisitem.author.dept | Otolaryngology | - |
crisitem.author.dept | Otolaryngology-NTUH | - |
crisitem.author.dept | Dentistry | - |
crisitem.author.dept | School of Dentistry | - |
crisitem.author.dept | Dentistry-NTUH | - |
crisitem.author.dept | Oral Biology | - |
crisitem.author.dept | Clinical Dentistry | - |
crisitem.author.dept | Clinical Medicine | - |
crisitem.author.dept | Oral Biology | - |
crisitem.author.dept | Microbiology | - |
crisitem.author.dept | Dentistry-NTUH | - |
crisitem.author.dept | School of Dentistry | - |
crisitem.author.orcid | 0000-0003-0964-0840 | - |
crisitem.author.orcid | 0000-0002-2538-558X | - |
crisitem.author.orcid | 0000-0001-8321-2575 | - |
crisitem.author.orcid | 0000-0002-6190-7162 | - |
crisitem.author.orcid | 0000-0002-5431-0712 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
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