https://scholars.lib.ntu.edu.tw/handle/123456789/569213
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | SANG-HENG KOK | en_US |
dc.contributor.author | JANG-JAER LEE | en_US |
dc.contributor.author | Hsu H.-C. | en_US |
dc.contributor.author | CHUN-PIN CHIANG | en_US |
dc.contributor.author | Kuo Y.-S. | en_US |
dc.contributor.author | YEN-PING KUO | en_US |
dc.date.accessioned | 2021-07-05T05:42:19Z | - |
dc.date.available | 2021-07-05T05:42:19Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 0904-2512 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0036688271&doi=10.1034%2fj.1600-0714.2002.00118.x&partnerID=40&md5=20429682ad846379d28b376aeacb9bb8 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/569213 | - |
dc.description.abstract | Background: Adenomatous polyposis coli (APC) gene mutations have been demonstrated not only in colorectal tumors but also in a variety of human cancers. Methods: To elucidate the possible roles of APC gene mutations in oral squamous cell carcinomas (OSCCs), we examined 40 untreated human primary OSCCs using polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) and DNA sequencing assays. Results: By screening nearly one-half of the coding region (codons 279-1673, including the MCR) of the APC gene, five missense mutations and a 1-base pair deletion were detected in five (12.5%) tumors, resulting in five amino-acid substitutions or a truncation of the APC protein. All patients with APC mutations were both areca quid chewers and tobacco smokers (P = 0.049). Conclusions: These results suggest that APC mutations may also contribute to the carcinogenesis of at least some OSCCs in Taiwan, especially for the users of areca quid and tobacco. | en_US |
dc.relation.ispartof | Journal of Oral Pathology and Medicine | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | Adenomatous Polyposis Coli Protein; Adult; Aged; Aged, 80 and over; Amino Acid Substitution; Areca; Base Pairing; Carcinoma, Squamous Cell; Chi-Square Distribution; Codon; Exons; Female; Frameshift Mutation; Gene Deletion; Genes, APC; Humans; Loss of Heterozygosity; Male; Middle Aged; Mouth Neoplasms; Mutation; Mutation, Missense; Polymerase Chain Reaction; Polymorphism, Single-Stranded Conformational; Sequence Analysis, DNA; Smoking; Statistics; Taiwan | - |
dc.title | Mutations of the adenomatous polyposis coli gene in areca quid and tobacco-associated oral squamous cell carcinomas in Taiwan | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1034/j.1600-0714.2002.00118.x | - |
dc.identifier.pmid | 12165057 | - |
dc.identifier.scopus | 2-s2.0-0036688271 | - |
dc.relation.pages | 395-401 | en_US |
dc.relation.journalvolume | 31 | en_US |
dc.relation.journalissue | 7 | en_US |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Dentistry | - |
crisitem.author.dept | School of Dentistry | - |
crisitem.author.dept | Dentistry-NTUH | - |
crisitem.author.dept | Dentistry | - |
crisitem.author.dept | Dentistry-NTUH | - |
crisitem.author.dept | School of Dentistry | - |
crisitem.author.dept | Oral Biology | - |
crisitem.author.dept | Dentistry | - |
crisitem.author.dept | School of Dentistry | - |
crisitem.author.dept | Dentistry-NTUH | - |
crisitem.author.orcid | 0000-0001-6445-8852 | - |
crisitem.author.orcid | 0000-0003-0964-0840 | - |
crisitem.author.orcid | 0000-0002-6190-7162 | - |
crisitem.author.orcid | 0000-0001-8321-2575 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 牙醫學系 |
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