https://scholars.lib.ntu.edu.tw/handle/123456789/569228
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | CHUN-PIN CHIANG | en_US |
dc.contributor.author | Huang J.-S. | en_US |
dc.contributor.author | Wang J.-T. | en_US |
dc.contributor.author | Liu B.-Y. | en_US |
dc.contributor.author | Kuo Y.-S. | en_US |
dc.contributor.author | Hahn L.-J. | en_US |
dc.contributor.author | YEN-PING KUO | en_US |
dc.date.accessioned | 2021-07-05T05:57:54Z | - |
dc.date.available | 2021-07-05T05:57:54Z | - |
dc.date.issued | 1999 | - |
dc.identifier.issn | 0904-2512 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033081344&doi=10.1111%2fj.1600-0714.1999.tb01999.x&partnerID=40&md5=97409f6dd6b7e1382a6c32b55388eefd | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/569228 | - |
dc.description.abstract | Expression of p53 protein was examined in oral squamous cell carcinoma (SCC) from patients who were areca quid (AQ) chewers and/or tobacco smokers, using anti-p53 antibodies with an immunoperoxidase technique. Positive p53 stain was observed in 47 of 81 (58%) cases of oral SCC. p53 overexpression was found to be higher in patients without AQ chewing and smoking habits than in patients with these two habits (80% vs 52%, P=0.076). No significant correlation was found between p53 expression and the patients' age, sex, cancer location, clinical staging, primary tumor TNM status, or histological differentiation of SCC. The Kaplan-Meier analysis showed that the prognosis for patients with p53-negative tumors was significantly better than that for patients with p53-positive tumors (P<0.05). A significant correlation was also observed between positive lymph node status and poor prognosis (P<0.05). These results suggest that p53 may serve as an adjuvant marker of poor survival in patients with oral SCCs in Taiwan. | en_US |
dc.publisher | Blackwell Munksgaard | en_US |
dc.relation.ispartof | Journal of Oral Pathology and Medicine | en_US |
dc.subject | Areca quid chewing; Oral squamous cell carcinoma; p53; Prognosis | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.title | Expression of p53 protein correlates with decreased survival in patients with areca quid chewing and smoking-associated oral squamous cell carcinomas in Taiwan | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1111/j.1600-0714.1999.tb01999.x | - |
dc.identifier.pmid | 9950253 | - |
dc.identifier.scopus | 2-s2.0-0033081344 | - |
dc.relation.pages | 72-76 | en_US |
dc.relation.journalvolume | 28 | en_US |
dc.relation.journalissue | 2 | en_US |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Oral Biology | - |
crisitem.author.dept | Dentistry | - |
crisitem.author.dept | School of Dentistry | - |
crisitem.author.dept | Dentistry-NTUH | - |
crisitem.author.orcid | 0000-0002-6190-7162 | - |
crisitem.author.orcid | 0000-0001-8321-2575 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 牙醫學系 |
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