https://scholars.lib.ntu.edu.tw/handle/123456789/569682
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | JANG-JAER LEE | en_US |
dc.contributor.author | SHIH-JUNG CHENG | en_US |
dc.contributor.author | Wang J.-J. | en_US |
dc.contributor.author | CHUN-PIN CHIANG | en_US |
dc.contributor.author | HAO-HUENG CHANG | en_US |
dc.contributor.author | HSIN-MING CHEN | en_US |
dc.contributor.author | SANG-HENG KOK | en_US |
dc.date.accessioned | 2021-07-06T04:08:47Z | - |
dc.date.available | 2021-07-06T04:08:47Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1043-3074 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84888012333&doi=10.1002%2fhed.23235&partnerID=40&md5=4d8294fe496a8510adbf796b3d5a3746 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/569682 | - |
dc.description.abstract | Background: Studies concerning prognostic factors specific for alendronate-related osteonecrosis of the jaws (ONJ) are rare. Methods We surveyed a cohort of 100 osteoporotic patients with 111 alendronate-related ONJ lesions treated during a 4-year period. Prognostic values of clinical variables and serum markers of bone turnover were assessed by univariate and multivariate analyses. Results: The cumulative complete response rate at 6 months was 48.65%. Serum bone-specific alkaline phosphatase (BSAP) level >10 μg/L, lesion depth ≦ 10 mm, and lesions in anterior regions denoted a better chance of healing within 6 months and the adjusted hazard ratios were 2.48 (95% confidence interval [CI], 1.41-4.37), 2.71 (95% CI, 1.57-4.70), and 3.94 (95% CI, 1.87-8.30), respectively. Conclusions: Early discovery of lesions and prevention of their deeper extension are crucial for improving the prognosis of alendronate-related ONJ. A higher pretreatment level of BSAP indicates a better prognosis. ? 2013 Wiley Periodicals, Inc. | en_US |
dc.relation.ispartof | Head and Neck | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | alendronic acid; alkaline phosphatase; amoxicillin; amoxicillin plus clavulanic acid; chlorhexidine; clindamycin; aged; article; bone turnover; cohort analysis; female; health survey; human; jaw osteonecrosis; major clinical study; male; priority journal; prognosis; treatment response; alendronate; BSAP; CTX; ONJ; osteoporosis; Adult; Aged; Aged, 80 and over; Alendronate; Alkaline Phosphatase; Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Biological Markers; Bisphosphonate-Associated Osteonecrosis of the Jaw; Bone Density Conservation Agents; Bone Remodeling; Chlorhexidine; Clindamycin; Cohort Studies; Collagen Type I; Debridement; Female; Humans; Male; Middle Aged; Mouthwashes; Multivariate Analysis; Osteoporosis; Peptides; Prognosis; Retrospective Studies | - |
dc.title | Factors predicting the prognosis of oral alendronate-related osteonecrosis of the jaws: A 4-year cohort study | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1002/hed.23235 | - |
dc.identifier.pmid | 23508560 | - |
dc.identifier.scopus | 2-s2.0-84888012333 | - |
dc.relation.pages | 1787-1795 | en_US |
dc.relation.journalvolume | 35 | en_US |
dc.relation.journalissue | 12 | en_US |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Dentistry | - |
crisitem.author.dept | Dentistry-NTUH | - |
crisitem.author.dept | School of Dentistry | - |
crisitem.author.dept | Oral Biology | - |
crisitem.author.dept | School of Dentistry | - |
crisitem.author.dept | Dentistry-NTUH | - |
crisitem.author.dept | Oral Biology | - |
crisitem.author.dept | School of Dentistry | - |
crisitem.author.dept | Dentistry | - |
crisitem.author.dept | Dentistry-NTUH | - |
crisitem.author.dept | Dentistry | - |
crisitem.author.dept | School of Dentistry | - |
crisitem.author.dept | Dentistry-NTUH | - |
crisitem.author.dept | Dentistry | - |
crisitem.author.dept | School of Dentistry | - |
crisitem.author.dept | Dentistry-NTUH | - |
crisitem.author.orcid | 0000-0003-0964-0840 | - |
crisitem.author.orcid | 0000-0003-4674-4892 | - |
crisitem.author.orcid | 0000-0002-6190-7162 | - |
crisitem.author.orcid | 0000-0003-3372-0699 | - |
crisitem.author.orcid | 0000-0002-6118-1234 | - |
crisitem.author.orcid | 0000-0001-6445-8852 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 臨床牙醫學研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。