https://scholars.lib.ntu.edu.tw/handle/123456789/570172
標題: | Cell-mediated immunity and head and neck cancer: With special emphasis on betel quid chewing habit | 作者: | Chang M.C. CHUN-PIN CHIANG Lin C.L. JANG-JAER LEE Hahn L.J. JIIANG-HUEI JENG |
公開日期: | 2005 | 卷: | 41 | 期: | 8 | 起(迄)頁: | 757-775 | 來源出版物: | Oral Oncology | 摘要: | Betel quid (BQ) chewing is popular in Taiwan, India, and many southeast-Asian countries. BQ chewing has strong association with the risk of oral leukoplakia (OL), oral submucous fibrosis (OSF), and oral cancer (OC). BQ components exhibit genotoxicity and may alter the structure of DNA, proteins and lipids, resulting in production of antigenicity. BQ ingredients are also shown to induce keratinocyte inflammation by stimulating the production of prostaglandins, TNF-α, IL-6, IL-8, and granulocyte-macrophage colony-stimulating factor (GM-CSF) in keratinocytes. These events may provoke tissue inflammation, early cell-mediated immunity (CMI), and immune surveillance in BQ chewers. However, BQ components also directly affect the functional activities of immunocompotent cells, and moreover tumor cells may hypo-respond to the CMI via diverse mechanisms such as induction of apoptosis of lymphocytes, induction of production of suppressor T cells, downregulation of MHC molecules in tumor cells, etc. Clinically, an alteration in lymphocyte subsets, a decrease in total number of lymphocytes, and a reduction in functional activities of CMI have been observed in isolated peripheral blood mononuclear cells (PBMC) and tumor infiltrated lymphocytes (TIL) in patients with OSF, OL or OC. Adaptation of tumor cells to immune system may promote clonal selection of resistant tumor cells, leading to immune tolerance. Future studies on effects of BQ components on CMI and humoral immunity in vitro and in vivo can be helpful for chemoprevention of BQ-related oral mucosal diseases. To elucidate how virus infection, tobacco, alcohol and BQ consumption, and other environmental exposure affect the immune status of patients with oral premalignant lesions or OC will help us to understand the immunopathogenesis of OC and to develop immunotherapeutic strategies for OC. ? 2005 Elsevier Ltd. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-23744456158&doi=10.1016%2fj.oraloncology.2005.01.007&partnerID=40&md5=07d586426a1ef8ba6374579bb1a60e0a https://scholars.lib.ntu.edu.tw/handle/123456789/570172 |
ISSN: | 1368-8375 | DOI: | 10.1016/j.oraloncology.2005.01.007 | SDG/關鍵字: | alcohol; DNA; granulocyte macrophage colony stimulating factor; interleukin 6; interleukin 8; lipid; protein; tumor necrosis factor alpha; alcohol consumption; apoptosis; betel nut; cell count; cellular immunity; chemoprophylaxis; cytokine production; DNA structure; down regulation; environmental exposure; genotoxicity; head and neck carcinoma; human; immune system; immunocompetent cell; immunological tolerance; immunopathogenesis; immunosurveillance; in vitro study; in vivo study; inflammation; keratinocyte; leukoplakia; lymphocyte; lymphocytopoiesis; major histocompatibility complex; mastication; mononuclear cell; mouth carcinoma; mouth disease; priority journal; prostaglandin blood level; reduction; review; suppressor cell; tumor associated leukocyte; tumor cell; Areca; Head and Neck Neoplasms; Humans; Immunity, Cellular; Lymphocyte Subsets; Lymphocytes, Tumor-Infiltrating; Mastication; Oral Submucous Fibrosis |
顯示於: | 臨床牙醫學研究所 |
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