https://scholars.lib.ntu.edu.tw/handle/123456789/570214
標題: | Blood profile of atrophic glossitis patients with thyroglobulin antibody/thyroid microsomal antibody positivity but without gastric parietal cell antibody positivity | 作者: | Kuo Y.-S. Wu Y.-H. JULIA YU-FONG CHANG YI-PING WANG Wu Y.-C. Sun A. |
公開日期: | 2019 | 出版社: | Elsevier B.V. | 卷: | 118 | 期: | 8 | 起(迄)頁: | 1218-1224 | 來源出版物: | Journal of the Formosan Medical Association | 摘要: | Background/purpose: Our previous study found that 304 of 1064 atrophic glossitis (AG) patients have thyroglobulin antibody (TGA) positivity and/or thyroid microsomal antibody (TMA) positivity but without gastric parietal cell antibody positivity (GPCA?TGA+/TMA+AG patients). This study mainly assessed whether the serum TGA/TMA positivity was significantly associated with anemia, hematinic deficiencies, and hyperhomocysteinemia in GPCA?TGA+/TMA+AG patients. Methods: The mean blood hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine levels were measured and compared between 304 GPCA?TGA+/TMA+AG patients and 476 GPCA-negative, TGA-negative, and TMA-negative AG patients (GPCA?TGA?TMA?AG patients) or 532 healthy control subjects. Results: We found significantly lower MCV and lower mean blood Hb and iron levels as well as significantly greater frquencies of microcytosis, macrocytosis, blood Hb, iron, vitamin B12, and folic acid deficiencies and hyperhomocysteinemia in 304 GPCA?TGA+/TMA+AG patients than in 532 healthy control subjects. However, no significant differences in the MCV and mean blood Hb, iron, vitamin B12, folic acid, and homocysteine leve1s as well as no significant differences in the frequencies of microcytosis, macrocytosis, blood Hb, iron, and folic acid deficiencies, and hyperhomocysteinemia were discovered between 304 GPCA?TGA+/TMA+AG patients and 476 GPCA?TGA?TMA?AG patients. The 304 GPCA?TGA+/TMA+AG patients had a significantly greater frquency of serum vitamin B12 deficiency than 476 GPCA?TGA?TMA?AG patients. Conclusion: The disease of AG itself plays a significant role in causing anemia, hematinic deficiencies, and hyperhomocysteinemia in GPCA?TGA+/TMA+AG patients. However, the serum TGA/TMA-positivity is not significantly associated with anemia, serum iron and folic acid deficiencies, and hyperhomocysteinemia in GPCA?TGA+/TMA+AG patients. ? 2019 Formosan Medical Association |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85064278333&doi=10.1016%2fj.jfma.2019.04.002&partnerID=40&md5=62969a0cedbb5b9cd292ae457f11918b https://scholars.lib.ntu.edu.tw/handle/123456789/570214 |
ISSN: | 0929-6646 | DOI: | 10.1016/j.jfma.2019.04.002 | SDG/關鍵字: | cyanocobalamin; folic acid; hemoglobin; homocysteine; iron; microsome antibody; parietal cell antibody; thyroglobulin antibody; autoantibody; cyanocobalamin; folic acid; hemoglobin; iron; adult; aged; anemia; antibody blood level; Article; atrophic glossitis; atrophy; B12 deficiency; blood cell count; controlled study; disease association; female; folic acid deficiency; glossitis; hemoglobin blood level; human; hyperhomocysteinemia; iron blood level; iron deficiency anemia; macrocytic anemia; major clinical study; male; megalocytosis; microcytic anemia; microcytosis; pernicious anemia; vitamin blood level; anemia; atrophy; blood; glossitis; immunology; mean corpuscular volume; middle aged; stomach parietal cell; Taiwan; very elderly; Adult; Aged; Aged, 80 and over; Anemia; Atrophy; Autoantibodies; Erythrocyte Indices; Female; Folic Acid; Glossitis; Hemoglobins; Humans; Hyperhomocysteinemia; Iron; Male; Middle Aged; Parietal Cells, Gastric; Taiwan; Vitamin B 12 |
顯示於: | 臨床牙醫學研究所 |
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