https://scholars.lib.ntu.edu.tw/handle/123456789/570218
標題: | Hematinic deficiencies and hyperhomocysteinemia in gastric parietal cell antibody-positive or gastric and thyroid autoantibodies-negative Behcet's disease patients | 作者: | CHUN-PIN CHIANG Wu Y.-H. JULIA YU-FONG CHANG YI-PING WANG Wu Y.-C. ANDY SUN |
公開日期: | 2019 | 出版社: | Elsevier B.V. | 卷: | 118 | 期: | 1P2 | 起(迄)頁: | 347-353 | 來源出版物: | Journal of the Formosan Medical Association | 摘要: | Background/Purpose: Our previous study found that 9 of 63 recurrent aphthous stomatitis (RAS)/Behcet's disease (BD) patients have serum gastric parietal cell antibody (GPCA) positivity. This study assessed whether serum GPCA positivity or RAS/BD itself was a significant factor causing hematinic deficiencies and hyperhomocysteinemia in GPCA-positive RAS/BD (GPCA + RAS/BD) or gastric and thyroid autoantibodies-negative RAS/BD (Abs ? RAS/BD) patients. Methods: The mean blood hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine levels were measured and compared between any two of three groups of 9 GPCA + RAS/BD patients, 41 Abs ? RAS/BD patients, and 126 healthy control subjects. Results: GPCA + RAS/BD patients had significantly lower mean blood Hb (for men only), iron (for men only), and vitamin B12 levels as well as a significantly higher mean serum homocysteine level than 126 healthy control subjects. Moreover, GPCA + RAS/BD patients had significantly greater frequencies of blood Hb, iron, and vitamin B12 deficiencies and of hyperhomocysteinemia than healthy control subjects. GPCA + RAS/BD patients did have a significantly lower mean serum vitamin B12 level and a significantly higher mean serum homocysteine level as well as significantly greater frequencies of vitamin B12 deficiency and of hyperhomocysteinemia than Abs ? RAS/BD patients. Moreover, Abs ? RAS/BD patients did have significantly lower mean blood Hb, iron, and folic acid levels and significantly greater frequencies of blood Hb and iron deficiencies than healthy control subjects. Conclusion: The GPCA is a major factor causing vitamin B12 deficiency and hyperhomocyteinemia in GPCA + RAS/BD patients. RAS/BD itself does play a significant role in causing anemia and hematinic deficiencies in both GPCA + RAS/BD and Abs ? RAS/BD patients. ? 2018 |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85048513387&doi=10.1016%2fj.jfma.2018.05.017&partnerID=40&md5=721e6352e016cb0036e21fdca7a44bee https://scholars.lib.ntu.edu.tw/handle/123456789/570218 |
ISSN: | 0929-6646 | DOI: | 10.1016/j.jfma.2018.05.017 | SDG/關鍵字: | cyanocobalamin; folic acid; hemoglobin; homocysteine; iron; parietal cell antibody; thyroid antibody; antianemic agent; autoantibody; cyanocobalamin; folic acid; hemoglobin; iron; abnormally high substrate concentration in blood; adult; aged; aphthous stomatitis; Article; Behcet disease; blood cell count; blood sampling; clinical article; comparative study; controlled study; cyanocobalamin deficiency; female; hematinic deficiency; hemoglobin blood level; human; hyperhomocysteinemia; iron deficiency; male; mean corpuscular volume; vitamin blood level; World Health Organization; adolescent; Behcet disease; blood; case control study; folic acid deficiency; hyperhomocysteinemia; immunology; middle aged; stomach; stomach parietal cell; Taiwan; thyroid gland; very elderly; young adult; Adolescent; Adult; Aged; Aged, 80 and over; Autoantibodies; Behcet Syndrome; Case-Control Studies; Female; Folic Acid; Folic Acid Deficiency; Hematinics; Hemoglobins; Humans; Hyperhomocysteinemia; Iron; Male; Middle Aged; Parietal Cells, Gastric; Stomach; Stomatitis, Aphthous; Taiwan; Thyroid Gland; Vitamin B 12; Vitamin B 12 Deficiency; Young Adult |
顯示於: | 臨床牙醫學研究所 |
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