Hematinic deficiencies and hyperhomocysteinemia in gastric parietal cell antibody-positive or gastric and thyroid autoantibodies-negative Behcet's disease patients
Journal
Journal of the Formosan Medical Association
Journal Volume
118
Journal Issue
1P2
Pages
347-353
Date Issued
2019
Author(s)
Abstract
Background/Purpose: Our previous study found that 9 of 63 recurrent aphthous stomatitis (RAS)/Behcet's disease (BD) patients have serum gastric parietal cell antibody (GPCA) positivity. This study assessed whether serum GPCA positivity or RAS/BD itself was a significant factor causing hematinic deficiencies and hyperhomocysteinemia in GPCA-positive RAS/BD (GPCA + RAS/BD) or gastric and thyroid autoantibodies-negative RAS/BD (Abs ? RAS/BD) patients. Methods: The mean blood hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine levels were measured and compared between any two of three groups of 9 GPCA + RAS/BD patients, 41 Abs ? RAS/BD patients, and 126 healthy control subjects. Results: GPCA + RAS/BD patients had significantly lower mean blood Hb (for men only), iron (for men only), and vitamin B12 levels as well as a significantly higher mean serum homocysteine level than 126 healthy control subjects. Moreover, GPCA + RAS/BD patients had significantly greater frequencies of blood Hb, iron, and vitamin B12 deficiencies and of hyperhomocysteinemia than healthy control subjects. GPCA + RAS/BD patients did have a significantly lower mean serum vitamin B12 level and a significantly higher mean serum homocysteine level as well as significantly greater frequencies of vitamin B12 deficiency and of hyperhomocysteinemia than Abs ? RAS/BD patients. Moreover, Abs ? RAS/BD patients did have significantly lower mean blood Hb, iron, and folic acid levels and significantly greater frequencies of blood Hb and iron deficiencies than healthy control subjects. Conclusion: The GPCA is a major factor causing vitamin B12 deficiency and hyperhomocyteinemia in GPCA + RAS/BD patients. RAS/BD itself does play a significant role in causing anemia and hematinic deficiencies in both GPCA + RAS/BD and Abs ? RAS/BD patients. ? 2018
SDGs
Other Subjects
cyanocobalamin; folic acid; hemoglobin; homocysteine; iron; parietal cell antibody; thyroid antibody; antianemic agent; autoantibody; cyanocobalamin; folic acid; hemoglobin; iron; abnormally high substrate concentration in blood; adult; aged; aphthous stomatitis; Article; Behcet disease; blood cell count; blood sampling; clinical article; comparative study; controlled study; cyanocobalamin deficiency; female; hematinic deficiency; hemoglobin blood level; human; hyperhomocysteinemia; iron deficiency; male; mean corpuscular volume; vitamin blood level; World Health Organization; adolescent; Behcet disease; blood; case control study; folic acid deficiency; hyperhomocysteinemia; immunology; middle aged; stomach; stomach parietal cell; Taiwan; thyroid gland; very elderly; young adult; Adolescent; Adult; Aged; Aged, 80 and over; Autoantibodies; Behcet Syndrome; Case-Control Studies; Female; Folic Acid; Folic Acid Deficiency; Hematinics; Hemoglobins; Humans; Hyperhomocysteinemia; Iron; Male; Middle Aged; Parietal Cells, Gastric; Stomach; Stomatitis, Aphthous; Taiwan; Thyroid Gland; Vitamin B 12; Vitamin B 12 Deficiency; Young Adult
Publisher
Elsevier B.V.
Type
journal article