https://scholars.lib.ntu.edu.tw/handle/123456789/570218
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | CHUN-PIN CHIANG | en_US |
dc.contributor.author | Wu Y.-H. | en_US |
dc.contributor.author | JULIA YU-FONG CHANG | en_US |
dc.contributor.author | YI-PING WANG | en_US |
dc.contributor.author | Wu Y.-C. | en_US |
dc.contributor.author | ANDY SUN | en_US |
dc.creator | Chiang C.-P.;Wu Y.-H.;Chang J.Y.-F.;Yi-Ping Wang;Wu Y.-C.;Sun A. | - |
dc.date.accessioned | 2021-07-07T02:12:40Z | - |
dc.date.available | 2021-07-07T02:12:40Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 0929-6646 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85048513387&doi=10.1016%2fj.jfma.2018.05.017&partnerID=40&md5=721e6352e016cb0036e21fdca7a44bee | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/570218 | - |
dc.description.abstract | Background/Purpose: Our previous study found that 9 of 63 recurrent aphthous stomatitis (RAS)/Behcet's disease (BD) patients have serum gastric parietal cell antibody (GPCA) positivity. This study assessed whether serum GPCA positivity or RAS/BD itself was a significant factor causing hematinic deficiencies and hyperhomocysteinemia in GPCA-positive RAS/BD (GPCA + RAS/BD) or gastric and thyroid autoantibodies-negative RAS/BD (Abs ? RAS/BD) patients. Methods: The mean blood hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine levels were measured and compared between any two of three groups of 9 GPCA + RAS/BD patients, 41 Abs ? RAS/BD patients, and 126 healthy control subjects. Results: GPCA + RAS/BD patients had significantly lower mean blood Hb (for men only), iron (for men only), and vitamin B12 levels as well as a significantly higher mean serum homocysteine level than 126 healthy control subjects. Moreover, GPCA + RAS/BD patients had significantly greater frequencies of blood Hb, iron, and vitamin B12 deficiencies and of hyperhomocysteinemia than healthy control subjects. GPCA + RAS/BD patients did have a significantly lower mean serum vitamin B12 level and a significantly higher mean serum homocysteine level as well as significantly greater frequencies of vitamin B12 deficiency and of hyperhomocysteinemia than Abs ? RAS/BD patients. Moreover, Abs ? RAS/BD patients did have significantly lower mean blood Hb, iron, and folic acid levels and significantly greater frequencies of blood Hb and iron deficiencies than healthy control subjects. Conclusion: The GPCA is a major factor causing vitamin B12 deficiency and hyperhomocyteinemia in GPCA + RAS/BD patients. RAS/BD itself does play a significant role in causing anemia and hematinic deficiencies in both GPCA + RAS/BD and Abs ? RAS/BD patients. ? 2018 | en_US |
dc.publisher | Elsevier B.V. | en_US |
dc.relation.ispartof | Journal of the Formosan Medical Association | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | cyanocobalamin; folic acid; hemoglobin; homocysteine; iron; parietal cell antibody; thyroid antibody; antianemic agent; autoantibody; cyanocobalamin; folic acid; hemoglobin; iron; abnormally high substrate concentration in blood; adult; aged; aphthous stomatitis; Article; Behcet disease; blood cell count; blood sampling; clinical article; comparative study; controlled study; cyanocobalamin deficiency; female; hematinic deficiency; hemoglobin blood level; human; hyperhomocysteinemia; iron deficiency; male; mean corpuscular volume; vitamin blood level; World Health Organization; adolescent; Behcet disease; blood; case control study; folic acid deficiency; hyperhomocysteinemia; immunology; middle aged; stomach; stomach parietal cell; Taiwan; thyroid gland; very elderly; young adult; Adolescent; Adult; Aged; Aged, 80 and over; Autoantibodies; Behcet Syndrome; Case-Control Studies; Female; Folic Acid; Folic Acid Deficiency; Hematinics; Hemoglobins; Humans; Hyperhomocysteinemia; Iron; Male; Middle Aged; Parietal Cells, Gastric; Stomach; Stomatitis, Aphthous; Taiwan; Thyroid Gland; Vitamin B 12; Vitamin B 12 Deficiency; Young Adult | - |
dc.title | Hematinic deficiencies and hyperhomocysteinemia in gastric parietal cell antibody-positive or gastric and thyroid autoantibodies-negative Behcet's disease patients | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.jfma.2018.05.017 | - |
dc.identifier.pmid | 29898820 | - |
dc.identifier.scopus | 2-s2.0-85048513387 | - |
dc.relation.pages | 347-353 | en_US |
dc.relation.journalvolume | 118 | en_US |
dc.relation.journalissue | 1P2 | en_US |
item.fulltext | no fulltext | - |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
crisitem.author.dept | Oral Biology | - |
crisitem.author.dept | Dentistry | - |
crisitem.author.dept | Dentistry-NTUH | - |
crisitem.author.dept | School of Dentistry | - |
crisitem.author.dept | Dentistry | - |
crisitem.author.dept | School of Dentistry | - |
crisitem.author.dept | Dentistry-NTUH | - |
crisitem.author.orcid | 0000-0002-6190-7162 | - |
crisitem.author.orcid | 0000-0002-3880-3787 | - |
crisitem.author.orcid | 0000-0001-9574-2194 | - |
crisitem.author.orcid | 0000-0002-4912-5424 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 臨床牙醫學研究所 |
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