https://scholars.lib.ntu.edu.tw/handle/123456789/570230
標題: | Gastric parietal cell and thyroid autoantibodies in patients with Behcet's disease | 作者: | Lin H.-P. Wu Y.-H. JULIA YU-FONG CHANG YI-PING WANG HSIN-MING CHEN Sun A. |
公開日期: | 2018 | 出版社: | Elsevier B.V. | 卷: | 117 | 期: | 6 | 起(迄)頁: | 505-511 | 來源出版物: | Journal of the Formosan Medical Association | 摘要: | Background/Purpose: Gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) were rarely examined in Behcet's disease (BD) patients. This study mainly assessed the frequencies of serum GPCA, TGA, and TMA positivities in 63 BD patients. Methods: The frequencies of serum GPCA, TGA, and TMA positivities in 63 BD patients, 19 major-typed recurrent aphthous stomatitis (RAS)/BD (major RAS/BD) patients, 44 minor-typed RAS/BD (minor RAS/BD) patients, 520 RAS patients, and 126 healthy control subjects were calculated and compared. Results: We found that 14.3%, 20.6%, and 20.6% of 63 BD patients, 21.1%, 21.1%, and 26.3% of 19 major RAS/BD patients, 11.4%, 20.5%, and 18.2% of 44 minor RAS/BD patients, 11.5%, 18.5%, and 18.3% of 520 RAS patients, and 1.6%, 2.4%, and 2.4% of 126 healthy control subjects had serum GPCA, TGA, and TMA positivities, respectively. BD, major RAS/BD, minor RAS/BD, and RAS patients all had significantly higher frequencies of serum GPCA, TGA, and TMA positivities than healthy control subjects (all P-values < 0.05). However, there were no significant differences in different serum autoantibody frequencies between BD, major RAS/BD, or minor RAS/BD patients and RAS patients. Of 16 TGA/TMA-positive BD patients whose serum thyroid-stimulating hormone (TSH) levels were measured, 87.5%, 6.3%, and 6.3% of these TGA/TMA-positive BD patients had normal, lower, and higher serum TSH levels, respectively. Conclusion: Approximately 35% BD patients have serum GPCA/TGA/TMA positivity. However, BD patients do not have significantly higher frequencies of serum GPCA, TGA, and TMA positivities than RAS patients. ? 2018 |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85043512239&doi=10.1016%2fj.jfma.2018.03.002&partnerID=40&md5=55a8f298925c9c7e8adfb64b07f31462 https://scholars.lib.ntu.edu.tw/handle/123456789/570230 |
ISSN: | 0929-6646 | DOI: | 10.1016/j.jfma.2018.03.002 | SDG/關鍵字: | parietal cell antibody; thyroglobulin antibody; thyroid antibody; thyroid microsomal antibody; thyrotropin; unclassified drug; anti-thyroglobulin; autoantibody; thyroid microsomal antibodies; adult; aged; antibody blood level; aphthous stomatitis; Article; Behcet disease; comparative study; controlled study; female; human; major clinical study; male; stomach parietal cell; thyrotropin blood level; adolescent; Behcet disease; blood; case control study; immunology; middle aged; stomach parietal cell; Taiwan; very elderly; young adult; Adolescent; Adult; Aged; Aged, 80 and over; Autoantibodies; Behcet Syndrome; Case-Control Studies; Female; Humans; Male; Middle Aged; Parietal Cells, Gastric; Stomatitis, Aphthous; Taiwan; Young Adult |
顯示於: | 臨床牙醫學研究所 |
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