https://scholars.lib.ntu.edu.tw/handle/123456789/570239
Title: | Antigastric parietal cell and antithyroid autoantibodies in patients with desquamative gingivitis | Authors: | JULIA YU-FONG CHANG CHUN-PIN CHIANG YI-PING WANG Wu Y.-C. HSIN-MING CHEN Sun A. |
Issue Date: | 2017 | Publisher: | Blackwell Publishing Ltd | Journal Volume: | 46 | Journal Issue: | 4 | Start page/Pages: | 307-312 | Source: | Journal of Oral Pathology and Medicine | Abstract: | Background: Desquamative gingivitis (DG) is principally associated with erosive oral lichen planus (EOLP), mucous membrane pemphigoid (MMP), and pemphigus vulgaris (PV). Methods: Serum autoantibodies including antigastric parietal cell antibody (GPCA), antithyroglobulin antibody (TGA), and antithyroid microsomal antibody (TMA) were measured in 500 patients with DG, 287 EOLP without DG (EOLP/DG?) patients, and 100 healthy control subjects. Results: The 500 patients with DG were diagnosed as having EOLP in 455 (91%), PV in 40 (8%), and MMP in five (1%) patients. We found that 37.0%, 43.6%, and 42.6% of 500 patients with DG, 39.6%, 46.4%, and 45.1% of 455 EOLP with DG (EOLP/DG) patients, and 18.5%, 27.5%, and 30.3% of 287 EOLP/DG? patients had the presence of GPCA, TGA, and TMA in their sera, respectively. DG, EOLP/DG, and EOLP/DG? patients all had a significantly higher frequency of GPCA, TGA, or TMA positivity than healthy control subjects (all P-values < 0.001). Moreover, 455 EOLP/DG patients had a significantly higher frequency of GPCA, TGA, or TMA positivity than 287 EOLP/DG? patients (all P-values < 0.001). Of 210 TGA/TMA-positive patients with DG whose serum thyroid-stimulating hormone (TSH) levels were measured, 84.3%, 6.7%, and 9.0% patients had normal, lower, and higher serum TSH levels, respectively. Conclusion: We conclude that 73.4% DG, 77.1% EOLP/DG, and 47.4% EOLP/DG? patients may have GPCA/TGA/TMA positivity in their sera. Because part of GPCA-positive patients may develop pernicious anemia, autoimmune atrophic gastritis, and gastric carcinoma, and part of TGA/TMA-positive patients may have thyroid dysfunction, these patients should be referred to medical department for further management. ? 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84992560099&doi=10.1111%2fjop.12490&partnerID=40&md5=37e0e24f576d3fd511b59d2f6d1dcff7 https://scholars.lib.ntu.edu.tw/handle/123456789/570239 |
ISSN: | 0904-2512 | DOI: | 10.1111/jop.12490 | SDG/Keyword: | parietal cell antibody; thyroglobulin; thyroglobulin antibody; thyroid antibody; thyroid microsomal antibody; thyrotropin; unclassified drug; anti-thyroglobulin; autoantibody; adult; aged; antibody blood level; antibody detection; Article; controlled study; desquamation; desquamative gingivitis; female; gingivitis; human; major clinical study; male; nonhuman; oral mucosal disease; priority journal; rat; scientific literature; thyroglobulin blood level; thyroid disease; thyrotropin blood level; case control study; gingivitis; immunology; lichen planus; middle aged; mucous membrane pemphigoid; pemphigus; stomach parietal cell; thyroid gland; very elderly; young adult; Adult; Aged; Aged, 80 and over; Autoantibodies; Case-Control Studies; Female; Gingivitis; Humans; Lichen Planus, Oral; Male; Middle Aged; Parietal Cells, Gastric; Pemphigoid, Benign Mucous Membrane; Pemphigus; Thyroid Gland; Young Adult |
Appears in Collections: | 臨床牙醫學研究所 |
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