https://scholars.lib.ntu.edu.tw/handle/123456789/570307
標題: | Clinicopathological Study of Oral Giant Cell Fibromas | 作者: | Kuo R.-C. YI-PING WANG HSIN-MING CHEN Sun A. Liu B.-Y. Kuo Y.-S. |
公開日期: | 2009 | 卷: | 108 | 期: | 9 | 起(迄)頁: | 725-729 | 來源出版物: | Journal of the Formosan Medical Association | 摘要: | Background/Purpose: Oral giant cell fibromas (GCFs) are found predominantly in Caucasians and rarely in other races. This retrospective study evaluated the clinicopathological features of 24 GCFs in Taiwanese patients. Methods: Twenty-four consecutive cases of oral GCF were investigated from 1987 to 2008. Clinical data and microscopic features were reviewed and analyzed. Results: The mean age of patients at the time of diagnosis was 29 years. Oral GCF occurred more commonly in patients between 11 and 40 years of age. There were 12 male and 12 female patients. The lesions were found more frequently on the tongue (8 cases) and gingiva (7 cases). The mean size of the lesion was 5.5 mm (range, 2-10 mm) in greatest dimension. GCF is misdiagnosed frequently as fibroma (19 cases) or papilloma (5 cases). All tumors were treated by total surgical excision and no recurrence was found after treatment. Microscopically, the GCF was a sessile or pedunculated mass covered with a thin layer of parakeratinized or orthokeratinized stratified squamous epithelium. The tumor was composed mainly of loose or dense fibrous connective tissue with well-formed capillaries and no inflammation. The consistent and diagnostic feature was the presence of large stellate giant cells, usually with one or two nuclei. Multinucleated giant cells were seen occasionally. These giant cells were most numerous in the connective tissue just beneath the epithelium. Conclusion: Oral GCFs show no significant sex predilection and occur in patients in the second to fourth decades of life. Usually, the lesions are < 1 cm in diameter and are found more frequently on the tongue and gingiva. GCF resembles fibroma or papilloma and is difficult to diagnose correctly at the first glance. All GCFs can be treated by conservative surgical excision without subsequent recurrence. ? 2009 Formosan Medical Association & Elsevier. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-71549115125&doi=10.1016%2fS0929-6646%2809%2960396-X&partnerID=40&md5=61a9ee98128b8e90ae5a2e9c484f3d98 https://scholars.lib.ntu.edu.tw/handle/123456789/570307 |
ISSN: | 0929-6646 | DOI: | 10.1016/S0929-6646(09)60396-X | SDG/關鍵字: | adult; article; cancer diagnosis; cancer recurrence; cancer size; Caucasian; child; clinical article; clinical evaluation; clinical examination; clinical feature; diagnostic error; female; fibroma; giant cell tumor; gingiva; histopathology; human; human tissue; male; microscopy; oral giant cell fibroma; papilloma; retrospective study; school child; squamous epithelium; Taiwan; tongue; tumor suppressor gene; tumor volume; Adolescent; Adult; Child; Female; Fibroma; Giant Cell Tumors; Humans; Male; Middle Aged; Mouth Neoplasms; Retrospective Studies |
顯示於: | 臨床牙醫學研究所 |
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