https://scholars.lib.ntu.edu.tw/handle/123456789/570608
標題: | A retrospective study on the therapeutic effects of sodium bicarbonate for adult in-hospital cardiac arrest | 作者: | CHIH-HUNG WANG CHENG-YI WU MENG-CHE WU WEI-TIEN CHANG CHIEN-HUA HUANG MIN-SHAN TSAI TSUNG-CHIEN LU Chou, Eric Hsieh, Yu-Lin WEN-JONE CHEN |
公開日期: | 11-六月-2021 | 卷: | 11 | 期: | 1 | 來源出版物: | Scientific reports | 摘要: | To investigate whether the effects of sodium bicarbonate (SB) during cardiopulmonary resuscitation (CPR) would be influenced by blood pH and administration timing. Adult patients experiencing in-hospital cardiac arrest (IHCA) from 2006 to 2015 were retrospectively screened. Early intra-arrest blood gas data were obtained within 10 min of CPR. Multivariable logistic regression analysis and generalised additive models were used for effect estimation and data exploration, respectively. A total of 1060 patients were included. Only 59 patients demonstrated favourable neurological status at hospital discharge. Blood pH ≤ 7.18 was inversely associated with favourable neurological outcome (odds ratio [OR], 0.24; 95% confidence interval [CI], 0.11-0.52; p value < 0.001) while SB use was not. In the interaction analysis for favourable neurological outcome, significant interactions were noted between SB use and time to SB (SB use × time to SB ≥ 20 min; OR 6.16; 95% CI 1.42-26.75; p value = 0.02). In the interaction analysis for survival to hospital discharge, significant interactions were noted between SB use and blood pH (Non-SB use × blood pH > 7.18; OR 1.56; 95% CI 1.01-2.41; p value = 0.05). SB should not be empirically administered for patients with IHCA since its effects may be influenced by blood pH and administration timing. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/570608 | ISSN: | 2045-2322 | DOI: | 10.1038/s41598-021-91936-3 |
顯示於: | 醫學院附設醫院 (臺大醫院) |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。