https://scholars.lib.ntu.edu.tw/handle/123456789/571408
標題: | Hypoglycemic diterpenoids from Tinospora crispa | 作者: | Lam S.-H. Ruan C.-T. Hsieh P.-H. MING-JAI SU SHOEI-SHENG LEE |
公開日期: | 2012 | 卷: | 75 | 期: | 2 | 起(迄)頁: | 153-159 | 來源出版物: | Journal of Natural Products | 摘要: | Three new diterpenoids, 2-O-lactoylborapetoside B (1), 6′-O- lactoylborapetoside B (2), and tinocrispol A (3), and nine known diterpenoids (4-12) were isolated from an EtOH extract of Tinospora crispa vines. Their structures were elucidated by spectroscopic analyses. The C-6 glucosyloxy group in borapetoside C (6) was revised to be α-oriented. The in vivo hypoglycemic activities of the major components, borapetosides A-C (4-6), were examined. Intraperitoneal injection of 4 and 6 (5 mg/kg) showed significant lowering of plasma glucose levels in normal and streptozotocin-induced type 1 diabetic mice. Borapetoside C increased glucose utilization in peripheral tissues and reduced hepatic gluconeogenesis, accounting for the hypoglycemic effect. ? 2012 The American Chemical Society and American Society of Pharmacognosy. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84863230279&doi=10.1021%2fnp200692v&partnerID=40&md5=19c2afecf45b6a6f84c012f4cbae1a7d https://scholars.lib.ntu.edu.tw/handle/123456789/571408 |
ISSN: | 1633864 | DOI: | 10.1021/np200692v | SDG/關鍵字: | 2 o lactoylborapetoside b; 6' o lactoylborapetoside b; alcohol; borapetol a; borapetol b; borapetoside A; borapetoside B; borapetoside c; borapetoside D; borapetoside E; borapetoside f; columbin; diterpenoid; glibenclamide; glucose; insulin; metformin; tinocrispol a; unclassified drug; animal cell; animal experiment; animal model; animal tissue; article; carbon nuclear magnetic resonance; controlled study; drug activity; drug isolation; gluconeogenesis; glucose blood level; hypoglycemia; in vivo study; insulin dependent diabetes mellitus; male; medicinal plant; mouse; non insulin dependent diabetes mellitus; nonhuman; proton nuclear magnetic resonance; streptozocin diabetes; structure activity relation; Tinospora crispa; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diterpenes; Hypoglycemic Agents; Mice; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Streptozocin; Tinospora; Mus; Tinospora crispa |
顯示於: | 藥學系 |
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