https://scholars.lib.ntu.edu.tw/handle/123456789/571541
標題: | Differential inhibition of reverse transcriptase and cellular DNA polymerase-α activities by lignans isolated from Chinese herbs, Phyllanthus myrtifolius Moon, and tannins from Lonicera japonica Thunb and Castanopsis hystrix | 作者: | Chang C.-W. Lin M.-T. SHOEI-SHENG LEE Liu K.C.S.C. Hsu F.-L. Lin J.-Y. |
關鍵字: | Caffeoylquinate; Galloylquinate; Galloylshikimate; Lignan; Reverse transcriptase inhibition | 公開日期: | 1995 | 卷: | 27 | 期: | 4 | 起(迄)頁: | 367-374 | 來源出版物: | Antiviral Research | 摘要: | Two lignans, phyllamycin B and retrojusticidin B isolated from Phyllanthus myrtifolius Moon have been demonstrated to have a strong inhibitory effect on human immunodeficiency virus-1 reverse transcriptase activity (HIV-1 RT), but much less inhibitory effect on human DNA polymerase-α (HDNAP-α) activity. Fifty percent inhibitory concentrations of phyllamycin B and retrojusticidin B were determined to be 3.5 and 5.5 μM for HIV-1 RT, and 289 and 989 μM for HDNAP-α, respectively. The mode of inhibition was found to be non-competitive inhibition with respect to template-primer and triphosphate substrate. Several tannins such as caffeoylquinates (CQs) isolated from Lonicera japonica Thunb, galloylquinates (GQs) and galloylshikimates (GSs) purified from Castanopsis hystrix were shown to have a much less selective inhibitory effect on HIV-1 RT. ? 1995. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0029162068&doi=10.1016%2f0166-3542%2895%2900020-M&partnerID=40&md5=bb8647f2ec1fae2e6567af2d9d8185a9 https://scholars.lib.ntu.edu.tw/handle/123456789/571541 |
ISSN: | 1663542 | DOI: | 10.1016/0166-3542(95)00020-M | SDG/關鍵字: | caffeoylquinate; chinese drug; dna polymerase; galloylquinate; galloylshikimate; lignan derivative; phyllamycin b; plant extract; retrojusticidin b; rna directed dna polymerase; tannin; unclassified drug; antiviral activity; article; drug activity; enzyme inhibition; human immunodeficiency virus; kinetics; nonhuman; priority journal; DNA Polymerase II; Drugs, Chinese Herbal; HIV-1 Reverse Transcriptase; Human; Kinetics; Lignans; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Structure-Activity Relationship; Support, Non-U.S. Gov't; Tannins; Castanopsis hystrix; Lonicera japonica; Phyllanthus myrtifolius |
顯示於: | 藥學系 |
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