https://scholars.lib.ntu.edu.tw/handle/123456789/571541
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Chang C.-W. | en_US |
dc.contributor.author | Lin M.-T. | en_US |
dc.contributor.author | SHOEI-SHENG LEE | en_US |
dc.contributor.author | Liu K.C.S.C. | en_US |
dc.contributor.author | Hsu F.-L. | en_US |
dc.contributor.author | Lin J.-Y. | en_US |
dc.date.accessioned | 2021-07-16T06:18:41Z | - |
dc.date.available | 2021-07-16T06:18:41Z | - |
dc.date.issued | 1995 | - |
dc.identifier.issn | 1663542 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0029162068&doi=10.1016%2f0166-3542%2895%2900020-M&partnerID=40&md5=bb8647f2ec1fae2e6567af2d9d8185a9 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/571541 | - |
dc.description.abstract | Two lignans, phyllamycin B and retrojusticidin B isolated from Phyllanthus myrtifolius Moon have been demonstrated to have a strong inhibitory effect on human immunodeficiency virus-1 reverse transcriptase activity (HIV-1 RT), but much less inhibitory effect on human DNA polymerase-α (HDNAP-α) activity. Fifty percent inhibitory concentrations of phyllamycin B and retrojusticidin B were determined to be 3.5 and 5.5 μM for HIV-1 RT, and 289 and 989 μM for HDNAP-α, respectively. The mode of inhibition was found to be non-competitive inhibition with respect to template-primer and triphosphate substrate. Several tannins such as caffeoylquinates (CQs) isolated from Lonicera japonica Thunb, galloylquinates (GQs) and galloylshikimates (GSs) purified from Castanopsis hystrix were shown to have a much less selective inhibitory effect on HIV-1 RT. ? 1995. | - |
dc.relation.ispartof | Antiviral Research | - |
dc.subject | Caffeoylquinate; Galloylquinate; Galloylshikimate; Lignan; Reverse transcriptase inhibition | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | caffeoylquinate; chinese drug; dna polymerase; galloylquinate; galloylshikimate; lignan derivative; phyllamycin b; plant extract; retrojusticidin b; rna directed dna polymerase; tannin; unclassified drug; antiviral activity; article; drug activity; enzyme inhibition; human immunodeficiency virus; kinetics; nonhuman; priority journal; DNA Polymerase II; Drugs, Chinese Herbal; HIV-1 Reverse Transcriptase; Human; Kinetics; Lignans; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Structure-Activity Relationship; Support, Non-U.S. Gov't; Tannins; Castanopsis hystrix; Lonicera japonica; Phyllanthus myrtifolius | - |
dc.title | Differential inhibition of reverse transcriptase and cellular DNA polymerase-α activities by lignans isolated from Chinese herbs, Phyllanthus myrtifolius Moon, and tannins from Lonicera japonica Thunb and Castanopsis hystrix | en_US |
dc.type | review | en |
dc.identifier.doi | 10.1016/0166-3542(95)00020-M | - |
dc.identifier.pmid | 8540756 | - |
dc.identifier.scopus | 2-s2.0-0029162068 | - |
dc.relation.pages | 367-374 | - |
dc.relation.journalvolume | 27 | - |
dc.relation.journalissue | 4 | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.openairetype | review | - |
item.grantfulltext | none | - |
crisitem.author.dept | Pharmacy | - |
crisitem.author.orcid | 0000-0002-6628-2448 | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 藥學系 |
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