https://scholars.lib.ntu.edu.tw/handle/123456789/572432
標題: | Longitudinal FDG-PET scan study of brain changes in mice with cancer-induced bone pain and after morphine analgesia | 作者: | WEN-YING LIN Chu, W.-H. Chao, T.-H.H. WEI-ZEN SUN CHEN-TUNG YEN |
公開日期: | 2019 | 出版社: | SAGE Publications Inc. | 卷: | 15 | 來源出版物: | Molecular Pain | 摘要: | Morphine is the most commonly used drug for treating physical and psychological suffering caused by advanced cancer. Although morphine is known to elicit multiple supraspinal analgesic effects, its behavioral correlates with respect to the whole-brain metabolic activity during cancer-induced bone pain have not been elucidated. We injected 4T1 mouse breast cancer cells into the left femur bone marrow cavity of BALB/c mice. All mice developed limb use deficits, mechanical allodynia, and hypersensitivity to cold, which were effectively suppressed with morphine. Serial 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) was performed for each mouse before cancer induction (0 day), after cancer-induced bone pain was established (14 days), and during effective morphine treatment (16 days). The longitudinal FDG-PET imaging analysis demonstrated that cancer-induced bone pain increased glucose uptake in the insular cortex and hypothalamus and decreased the activity of the retrosplenial cortex. Morphine reversed the activation of the insular cortex and hypothalamus. Furthermore, morphine activated the amygdala and rostral ventromedial medulla and suppressed the activity of anterior cingulate cortex. Our findings of hypothalamic and insular cortical activation support the hypothesis that cancer-induced bone pain has strong inflammatory and affective components in freely moving animals. Morphine may provide descending inhibitory and facilitatory actions in the treatment of cancer-induced bone pain in a clinical setting. ? The Author(s) 2019. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85065202887&doi=10.1177%2f1744806919841194&partnerID=40&md5=55ebf3a667c29e4be5c0841c0e101144 https://scholars.lib.ntu.edu.tw/handle/123456789/572432 |
ISSN: | 1744-8069 | DOI: | 10.1177/1744806919841194 | SDG/關鍵字: | fluorodeoxyglucose f 18; morphine; fluorodeoxyglucose f 18; morphine; 4T1 cell line; advanced cancer; allodynia; animal cell; animal model; animal tissue; Article; bone pain; carcinogenesis; controlled study; dorsal anterior cingulate cortex; experimental behavioral test; female; glucose metabolism; histopathology; hypersensitivity; hypothalamus; image analysis; insula; locomotion; mouse; nonhuman; nuclear magnetic resonance imaging; positron emission tomography; priority journal; retrosplenial cortex; rostral ventromedial medulla; animal; Bagg albino mouse; bone tumor; brain; cancer pain; diagnostic imaging; hyperalgesia; positron emission tomography; procedures; tumor cell line; Animals; Bone Neoplasms; Brain; Cancer Pain; Cell Line, Tumor; Female; Fluorodeoxyglucose F18; Hyperalgesia; Mice; Mice, Inbred BALB C; Morphine; Positron-Emission Tomography |
顯示於: | 醫學院附設癌醫中心醫院(臺大癌醫) |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。