https://scholars.lib.ntu.edu.tw/handle/123456789/573153
標題: | Immunomodulatory Effects of Taiwanese Neolitsea Species on Th1 and Th2 Functionality | 作者: | Cheng Y.-H Lin Y.-C Chen I.-S Liu S.-D Li J.-H CHIA-CHI WANG |
關鍵字: | CD28 antigen; CD3 antigen; CD4 antigen; gamma interferon; interleukin 10; interleukin 17; interleukin 2; interleukin 4; cytokine; gamma interferon; herbaceous agent; interleukin 10; interleukin 17; adaptive immunity; animal cell; Article; cell viability; controlled study; cytokine production; cytokine release; immunomodulation; immunostimulation; Lauraceae; lymphocyte function; male; mouse; Neolitsea aciculata; Neolitsea aciculata var variabillima; Neolitsea acuminatissima; Neolitsea buisanensis; Neolitsea daibuensis; Neolitsea hiiranensis; Neolitsea konishii; Neolitsea parvigemma; Neolitsea sericea var aurata; Neolitsea villosa; nonhuman; spleen cell; Taiwanese; Th1 cell; Th2 cell; animal; biosynthesis; CD4+ T lymphocyte; chemistry; cytology; drug effects; human; immunology; Lauraceae; metabolism; spleen; Th1 cell; Th1 Th2 balance; Th2 cell; Animals; CD4-Positive T-Lymphocytes; Cytokines; Drugs, Chinese Herbal; Humans; Immunomodulation; Interferon-gamma; Interleukin-10; Interleukin-17; Lauraceae; Mice; Spleen; Th1 Cells; Th1-Th2 Balance; Th2 Cells | 公開日期: | 2017 | 卷: | 2017 | 來源出版物: | Journal of Immunology Research | 摘要: | Neolitsea species, medicinal plants belonging to Lauraceae, contain rich alkaloids, steroids, sesquiterpenoids, and triterpenoids which possess antimicrobial, antioxidant, and anti-inflammatory bioactivities. However, species differences in the immunomodulatory effects and evidence pertaining to the effects of Neolitsea species on adaptive immunity are scarce. This study aimed to evaluate the immunomodulatory properties of ten Taiwanese Neolitsea plants on T helper (Th) cell functionality, especially Th1 and Th2. Most of the 29 crude extracts of Neolitsea were not toxic to splenocytes, except N. buisanensis roots. N. aciculata and N. villosa leaf extracts possessed differential immunomodulatory effects on Th1/Th2 balance. N. aciculata var. variabillima and N. hiiranensis leaf extracts attenuated both Th1 and Th2 cytokines while N. konishii dramatically suppressed IFN-γ production. As N. aciculata var. variabillima and N. konishii leaf extracts significantly attenuated Th1 functionality, we further evaluated their effects on CD4 cells under CD3/CD28 stimulation. N. aciculata var. variabillima significantly suppressed IFN-γ, IL-10, and IL-17, demonstrating the broad suppressive effects on T helper cells; N. konishii significantly suppressed IFN-γ and IL-10 production, while the production of IL-17 was not altered. Collectively, these data demonstrated that leaf extracts of Taiwanese Neolitsea species contain phytochemicals with potentials to be developed as selective immunomodulators. ? 2017 Yin-Hua Cheng et al. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85026517933&doi=10.1155%2f2017%2f3529859&partnerID=40&md5=e8407d2c75cce28d6643c0e37fe46de4 https://scholars.lib.ntu.edu.tw/handle/123456789/573153 |
ISSN: | 23148861 | DOI: | 10.1155/2017/3529859 |
顯示於: | 獸醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。