|Title:||Diagnosis of meningeal melanomatosis in a dog using magnetic resonance imaging and cerebrospinal fluid findings||Authors:||Wu C.-C
|Keywords:||gadolinium pentetate meglumine; melan A; prednisolone; adult; animal experiment; animal tissue; anisocoria; Article; autopsy; bleeding; brain stem; cell infiltration; cerebrospinal fluid; cervical spinal cord; cranial nerve; cytology; dog; erythrocyte; female; gray matter; heart rate; hemisphere; histopathology; immunocytochemistry; immunoreactivity; limb weakness; macrophage; melanogenesis; melanoma; meningeal melanomatosis; meningeal melanomatosis; meningoencephalitis; meninx; metastasis; monocyte; neurologic examination; neutrophil; nonhuman; nuclear magnetic resonance imaging; paresis; x-ray computed tomography||Issue Date:||2021||Journal Volume:||83||Journal Issue:||1||Start page/Pages:||94-99||Source:||Journal of Veterinary Medical Science||Abstract:||
A 13-year-old spayed female Labrador Retriever was presented with severe progressive tetraparesis. The neuroanatomic localization was the C1–C5 spinal cord segments with brainstem or cranial nerve involvement. Magnetic resonance imaging revealed diffuse T1-weighted and T2-weighted hyperintense lesions with strong contrast enhancement spreading through meninges of the cervical spinal cord and the brain. Few small round areas showing T1-weighted hyperintensity and T2-weighted hypointensity were scattered within the lesions. Cerebrospinal fluid analysis revealed neoplastic round cells and possible melanocytes. Malignant melanoma was suspected. At necropsy, the brain and the entire spinal cord were covered with thick, dark membranous tissue. Based on histopathologic findings, a positive response against Melan-A, and no melanoma identified outside the central nervous system, primary meningeal melanomatosis was diagnosed. ? 2021 The Japanese Society of Veterinary Science.
|Appears in Collections:||臨床動物醫學研究所|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.