https://scholars.lib.ntu.edu.tw/handle/123456789/573322
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Terrell J.L | en_US |
dc.contributor.author | HSUAN-CHEN WU et al. | en_US |
dc.creator | Terrell J.L;Tschirhart T;Jahnke J.P;Stephens K;Liu Y;Dong H;Hurley M.M;Pozo M;McKay R;Tsao C.Y;Wu H.-C;Vora G;Payne G.F;Stratis-Cullum D.N;Bentley W.E. | - |
dc.date.accessioned | 2021-07-26T10:04:03Z | - |
dc.date.available | 2021-07-26T10:04:03Z | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 17483387 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103386323&doi=10.1038%2fs41565-021-00878-4&partnerID=40&md5=1dd44d47baeb325ee6eaef6e7680113c | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/573322 | - |
dc.description.abstract | We developed a bioelectronic communication system that is enabled by a redox signal transduction modality to exchange information between a living cell-embedded bioelectronics interface and an engineered microbial network. A naturally communicating three-member microbial network is ‘plugged into’ an external electronic system that interrogates and controls biological function in real time. First, electrode-generated redox molecules are programmed to activate gene expression in an engineered population of electrode-attached bacterial cells, effectively creating a living transducer electrode. These cells interpret and translate electronic signals and then transmit this information biologically by producing quorum sensing molecules that are, in turn, interpreted by a planktonic coculture. The propagated molecular communication drives expression and secretion of a therapeutic peptide from one strain and simultaneously enables direct electronic feedback from the second strain, thus enabling real-time electronic verification of biological signal propagation. Overall, we show how this multifunctional bioelectronic platform, termed a BioLAN, reliably facilitates on-demand bioelectronic communication and concurrently performs programmed tasks. ? 2021, The Author(s), under exclusive licence to Springer Nature Limited. | - |
dc.relation.ispartof | Nature Nanotechnology | - |
dc.subject | Gene expression; Molecules; Signal transduction; Biological functions; Biological signals; Electronic feedback; Electronic signals; Microbial communities; Molecular communication; Quorum sensing molecules; Therapeutic peptides; Electrodes; Article; bacterial cell; bacterial strain; coculture; controlled study; electrogenetics; feedback system; gene expression; gene technology; genetic engineering; information processing; microbial community; nonhuman; oxidation reduction reaction; plankton; protein secretion; quorum sensing; signal transduction | - |
dc.title | Bioelectronic control of a microbial community using surface-assembled electrogenetic cells to route signals | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1038/s41565-021-00878-4 | - |
dc.identifier.pmid | 33782589 | - |
dc.identifier.scopus | 2-s2.0-85103386323 | - |
dc.relation.pages | 688-697 | - |
dc.relation.journalvolume | 16 | - |
dc.relation.journalissue | 6 | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Biochemical Science and Technology | - |
crisitem.author.dept | Center for Environmental Safety & Health | - |
crisitem.author.orcid | 0000-0002-7837-1333 | - |
crisitem.author.parentorg | College of Life Science | - |
crisitem.author.parentorg | Administrative Unit | - |
顯示於: | 生化科技學系 |
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