https://scholars.lib.ntu.edu.tw/handle/123456789/575652
DC Field | Value | Language |
---|---|---|
dc.contributor.author | TAO-MIN HUANG | en_US |
dc.contributor.author | VIN-CENT WU | en_US |
dc.contributor.author | YU-FENG LIN | en_US |
dc.contributor.author | Wang, Jian-Jhong | en_US |
dc.contributor.author | Shiao, Chih-Chung | en_US |
dc.contributor.author | Chen, Likwang | en_US |
dc.contributor.author | SHIH-CHIEH CHUEH | en_US |
dc.contributor.author | Chueh, Eric | en_US |
dc.contributor.author | SHAO-YU YANG | en_US |
dc.contributor.author | TAI-SHUAN LAI | en_US |
dc.contributor.author | SHUEI-LIONG LIN | en_US |
dc.contributor.author | Chu, Tzong-Shinn | en_US |
dc.contributor.author | KWAN-DUN WU | en_US |
dc.contributor.author | National Taiwan University Hospital Study Group on Acute Renal Failure (NSARF) | en_US |
dc.date.accessioned | 2021-08-02T02:49:40Z | - |
dc.date.available | 2021-08-02T02:49:40Z | - |
dc.date.issued | 2018-09-17 | - |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/575652 | - |
dc.description.abstract | Although statin treatment is recommended for patients with chronic kidney disease (CKD) stages I⁻IV, its potential benefits have not been reported in advanced CKD patients. Non-diabetic patients with advanced CKD (pre-dialysis patients, estimated glomerular filtration rate <15 mL/min/1.73 m²) were enrolled from a National Health Insurance Research Database with a population of 23 million. Statin users and non-users were matched using propensity scoring and analyzed using Cox proportional hazards models, taking mortality as a competing risk with subsequent end-stage renal disease (ESRD) and statin doses as time-dependent variables. A total of 2551 statin users and 7653 matched statin non-users were identified from a total 14,452 patients with advanced CKD. Taking mortality as a competing risk, statin use did not increase the risk of new-onset diabetes mellitus (NODM) or decrease the risk of de novo major adverse cardiovascular events (MACE), but reduced all-cause mortality (hazard ratio (HR) = 0.59 [95% CI 0.42⁻0.84], p = 0.004) and sepsis-related mortality (HR = 0.53 [95% CI 0.32⁻0.87], p = 0.012). For advanced CKD patients, statin was neither associated with increased risks of developing NODM, nor with decreased risk of de novo MACE occurrence, but with a reduced risk of all-cause mortality, mainly septic deaths. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Journal of clinical medicine | en_US |
dc.subject | chronic kidney disease; diabetes; major adverse cardiovascular events; mortality; sepsis; statin | en_US |
dc.subject | Chronic kidney disease; Diabetes; Major adverse cardiovascular events; Mortality; Sepsis; Statin | en_US |
dc.subject.other | antianemic agent; atorvastatin; fluindostatin; hydroxymethylglutaryl coenzyme A reductase inhibitor; mevinolin; pravastatin; rosuvastatin; simvastatin; adult; all cause mortality; Article; cardiovascular disease; cerebrovascular accident; chronic kidney failure; cohort analysis; comorbidity; controlled study; coronary angiography; coronary artery bypass graft; diabetes mellitus; dialysis; end stage renal disease; female; follow up; glomerulus filtration rate; heart infarction; human; hyperglycemia; infection; kidney transplantation; major clinical study; male; middle aged; retrospective study; sepsis; treatment outcome | - |
dc.subject.other | [SDGs]SDG3 | - |
dc.title | Effects of Statin Use in Advanced Chronic Kidney Disease Patients | en_US |
dc.type | journal article | en_US |
dc.identifier.doi | 10.3390/jcm7090285 | - |
dc.identifier.pmid | 30227675 | - |
dc.relation.journalvolume | 7 | en_US |
dc.relation.journalissue | 9 | en_US |
item.grantfulltext | none | - |
item.languageiso639-1 | en | - |
item.fulltext | no fulltext | - |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUHHC | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Medicine-NTUCC | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Urology | - |
crisitem.author.dept | Urology-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Medicine-NTUCC | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Physiology | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Integrated Diagnostics and Therapeutics-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0002-9387-0798 | - |
crisitem.author.orcid | 0000-0001-7935-0991 | - |
crisitem.author.orcid | 0000-0002-4350-7755 | - |
crisitem.author.orcid | 0000-0002-0713-4904 | - |
crisitem.author.orcid | 0000-0001-9170-2566 | - |
crisitem.author.orcid | 0000-0002-0552-372X | - |
crisitem.author.orcid | 0000-0002-1041-5571 | - |
crisitem.author.orcid | 0000-0002-3339-1509 | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | NTU Hsin-Chu Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Cancer Center (NTUCC) | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Cancer Center (NTUCC) | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
Appears in Collections: | 醫學系 |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.