https://scholars.lib.ntu.edu.tw/handle/123456789/575841
Title: | Long-Term Near-Infrared Signal Tracking of the Therapeutic Changes of Glioblastoma Cells in Brain Tissue with Ultrasound-Guided Persistent Luminescent Nanocomposites | Authors: | Cheng C.-L Chan M.-H Feng S.-J Hsiao M RU-SHI LIU |
Keywords: | Blood; Chemotherapy; Controlled drug delivery; Image enhancement; Luminescence; Nanosystems; Signal to noise ratio; Targeted drug delivery; Tissue; Ultrasonics; Blood-brain barrier; Glioblastoma cells; Image tracking; Luminescent nanoparticle; Near-infrared emissions; Physical barriers; Therapeutic effects; Ultrasound guided; Infrared devices; alkylating agent; nanocomposite; temozolomide; animal; blood brain barrier; brain tumor; cell survival; chemical structure; chemistry; drug effect; experimental neoplasm; glioblastoma; human; infrared radiation; particle size; pathology; surface property; tumor cell line; ultrasound; ultrasound therapy; Animals; Antineoplastic Agents, Alkylating; Blood-Brain Barrier; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Glioblastoma; Humans; Infrared Rays; Molecular Structure; Nanocomposites; Neoplasms, Experimental; Particle Size; Surface Properties; Temozolomide; Ultrasonic Therapy; Ultrasonic Waves | Issue Date: | 2021 | Journal Volume: | 13 | Journal Issue: | 5 | Start page/Pages: | 6099-6108 | Source: | ACS Applied Materials and Interfaces | Abstract: | The blood-brain barrier (BBB) is a physical barrier that selectively prevents certain substances from entering the brain through the blood. The BBB protects the brain from germs and causes difficulty in intracranial treatment. The chemotherapy drug temozolomide (TMZ), embedded in nanobubbles (NBs) and combined with persistent luminescent nanoparticles (PLNs), has been used to treat glioblastoma (GBM) effectively through image tracking. Through ultrasound induction, NBs produce cavitation that temporarily opens the BBB. Additionally, the PLNs release near-infrared emission and afterglow, which can penetrate deep tissues and improve the signal-to-noise ratio of bioimages. In this work, the nanosystem crossed the BBB for drug delivery and image tracking over time, allowing the enhancement of the drug's therapeutic effect on GBM. We hope that this nanosystem can be applied to the treatment of different brain diseases by embedding different drugs in NBs. ? 2021 American Chemical Society. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100618702&doi=10.1021%2facsami.0c22489&partnerID=40&md5=ec5cf1043a5f50c64fc200b1a5c00c95 https://scholars.lib.ntu.edu.tw/handle/123456789/575841 |
ISSN: | 19448244 | DOI: | 10.1021/acsami.0c22489 | SDG/Keyword: | Blood; Chemotherapy; Controlled drug delivery; Image enhancement; Luminescence; Nanosystems; Signal to noise ratio; Targeted drug delivery; Tissue; Ultrasonics; Blood-brain barrier; Glioblastoma cells; Image tracking; Luminescent nanoparticle; Near-infrar |
Appears in Collections: | 化學系 |
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