https://scholars.lib.ntu.edu.tw/handle/123456789/577313
標題: | Solitary tibial lesion as the initial presentation of Langerhans cell histiocytosis: report of two cases and literature review | 作者: | Lin, Chih-Yang CHIA-CHE LEE KUAN-WEN WU CHANG-TSU YUAN Kuo, Ken-Nan TING-MING WANG |
關鍵字: | LCH; Langerhans cell histiocytosis; Taiwan Paediatric Oncology Group; eosinophilic granuloma | 公開日期: | 一月-2021 | 卷: | 49 | 期: | 1 | 來源出版物: | The Journal of international medical research | 摘要: | The various presentations of osseous Langerhans cell histiocytosis (LCH) make it difficult to distinguish from other bone diseases. In addition, there is no universally accepted protocol for managing osseous LCH for single non-central nervous system-risk lesions. Here, the rare cases of two paediatric patients, aged 1 and 2 years, who presented with a solitary tibial lesion at time of LCH diagnosis, are reported. One patient progressed to multiple lesions after curettage of the original lesion. Subsequently, both patients received preventive chemotherapy using the Taiwan Paediatric Oncology Group (TPOG) revised protocol for treating low risk patients with LCH, namely, TPOG LCH2002-LR. After receiving this treatment, which included a schedule of prednisolone and vincristine for 6 weeks, followed by prednisolone, vincristine and 6-mercaptopurine for a further 48 weeks, both patients are free from recurrence or progression. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/577313 | ISSN: | 03000605 | DOI: | 10.1177/0300060520982826 | SDG/關鍵字: | mercaptopurine; prednisolone; vincristine; prednisolone; vincristine; Article; bone lesion; case report; child; clinical article; clinical feature; drug effect; fever; human; human tissue; immunohistochemistry; Langerhans cell histiocytosis; limp (gait); male; nuclear magnetic resonance imaging; physical examination; preschool child; recurrent disease; tibial shaft; treatment duration; bone disease; diagnostic imaging; infant; Taiwan; Bone Diseases; Child; Child, Preschool; Histiocytosis, Langerhans-Cell; Humans; Infant; Prednisolone; Taiwan; Vincristine |
顯示於: | 醫學系 |
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